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Invitrogen
STEP Polyclonal Antibody
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Product Details
PA5-111009
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Protein corresonding to Human STEP. Recombinant protein control fragment (Product #RP-95603).
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PEDRRQSVSR QPSFTYSEWM EEKIEDDFLD LDPVPETPVF DCVMDIKPEA DPTSLTVKSM GL
Highest antigen sequence indentity to the following orthologs: Mouse - 94%, Rat - 97%.
Target Information
Reversible phosphorylation of tyrosine residues is a key regulatory mechanism for numerous cellular events such as proliferation, differentiation, gene expression and migration. Abnormalities in tyrosine phosphorylation play a role in the pathogenesis of numerous inherited or acquired human diseases from cancer to immune deficiencies. There are at least 107 genes coding for PTPs (protein tyrosine phosphatases) in the human genome. All known PTPs contain a highly conserved 12 amino acid catalytic domain and are further distinguished on the basis of additional structural motifs. The receptor-like PTPs exhibit an extracellular domain, a single transmembrane and one or two intracellular phosphatase domains. The nonreceptor cytoplasmic PTPs contain a single phosphatase domain and additional amino acid sequences that are homologous to motifs found in other classes of proteins. Protein tyrosine phosphatases PTPN5 (STEP), PTPRR and PTPN7 comprise a family of phosphatases that specifically inactivate MAPKs (mitogen-activated protein kinases). There are multiple forms of STEP in the adult rat brain which show differential enrichment in brain regions implicated in aspects of cognitive, affective, and motor behaviors. Some of the STEP isoforms are generated through alternative splicing of a single STEP gene and each has unique intracellular targets and functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ14427; Neural-specific protein-tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched); protein-tyrosine phosphatase striatum-enriched; PTN5; PTP STEP; PTPN 5; STEP; striatal-enriched protein tyrosine phosphatase; Striatum-enriched protein-tyrosine phosphatase; Tyrosine-protein phosphatase non-receptor type 5
Gene Aliases: PTPN5; PTPSTEP; STEP; STEP61
UniProt ID: (Human) P54829
Entrez Gene ID: (Human) 84867
positive regulation of protein phosphorylation
response to amphetamine
positive regulation of receptor internalization
protein dephosphorylation
positive regulation of neuron projection development
positive regulation of protein import into nucleus, translocation
peptidyl-tyrosine dephosphorylation
exploration behavior
response to immobilization stress
response to drug
negative regulation of MAP kinase activity
positive regulation of long-term synaptic potentiation
positive regulation of neuron death
response to acetylsalicylate
positive regulation of protein targeting to mitochondrion
positive regulation of response to drug
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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