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Invitrogen
STIM1 Polyclonal Antibody
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FIGURE: 1 / 2
STIM1 Antibody (PA5-85387) in ICC/IF
Immunocytochemistry-Immunofluorescence analysis of STIM1 was performed in DIV10 rat E18 primary cortical neuron cells fixed in 4% paraformaldehyde at RT for 15 min. Green: STIM1 Polyclonal Antibody (Product # PA5-85387) diluted at 1:500. Red: alpha Tubulin, stained by alpha Tubulin antibody. Blue: Fluoroshield with DAPI.
Product Details
PA5-85387
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
C. elegans
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the Intracellular domain of human STIM1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.79 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Pig (88%), Rhesus Monkey (98%), Bovine (94%).
Positive Control: mouse thymus.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
STIM1 (stromal interacting molecule; also known as GOK) acts as a sensor of calcium depletion within the endoplasmic reticulum and transduces the signal to Orai1, the presumptive CRAC channel at the plasma membrane. Following decrease of luminal calcium concentration, STIM1 oligomerizes and induces Orai1 to enable entry of extracellular calcium into the cytoplasm. However, the precise mechanism of STIM1-Orai1 interaction has not been elucidated yet. Many questions also remain to be solved around STIM1 functional distribution. It turns out that STIM1 associates with growing ends of microtubules and is involved in endoplasmic reticulum tubule extension.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: stim1 {ECO:0000312|RGD:1306831}; STIM1L; Stromal interaction molecule 1
Gene Aliases: D11S4896E; GOK; IMD10; SIM; STIM1; STRMK; TAM; TAM1
UniProt ID: (Human) Q13586, (Mouse) P70302, (Rat) P84903
Entrez Gene ID: (Human) 6786, (Mouse) 20866, (Rat) 361618
store-operated calcium entry
detection of calcium ion
cellular calcium ion homeostasis
activation of store-operated calcium channel activity
regulation of calcium ion transport
enamel mineralization
regulation of cardiac conduction
transport
ion transport
cation transport
calcium ion transport
myotube differentiation
calcium ion transmembrane transport
regulation of store-operated calcium entry
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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