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Invitrogen
STIM2 Polyclonal Antibody
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FIGURE: 1 / 4
STIM2 Antibody (PA5-77331) in ICC/IF
Immunocytochemistry analysis of STIM2 in paraformaldehyde-fixed and permeabilized rat basophilic leukemia cells. A, D) Samples were probed with STIM2 polyclonal antibody (Product # PA5-77331) at a dilution of 1:100, and incubated with goat-anti-rabbit-AlexaFluor-555 and Hoechst. B, E) Nuclei stained image. C) Merged images of Panels A and B. F) Merged images of Panels D and E.
Product Details
PA5-77331
Applications
Tested Dilution
Publications
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide SAEKQWEVPDTASEC, corresponding to amino acid residues 583-597 of human STIM2
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
Product Specific Information
Product is shipped at room temperature as a lyophilized powder and should be stored at -20C upon receipt.
Reconstitution: Add 50 µL of deionized water.
Target Information
In T lymphocytes, the sole pathway for Ca++ entry following antigen-receptor binding is through store-operated Ca++-release-activated Ca++ (CRAC) channels. These channels are made up of the pore-forming subunit ORAI1 and the stromal interaction molecule 1 (STIM1), a protein that functions as a Ca++ sensor and activates the CRAC channels, migrating to the plasma membrane from endoplasmic reticulum (ER)-like sites which act as the Ca++ store. A related molecule, STIM2, acts to inhibit the STIM1-mediated store-operated Ca++ entry, and can form complexes with STIM1, suggesting they may play a coordinated role in controlling Ca++ entry. At least three isoforms of STIM2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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