This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 100%; Rat: 100%
STING is a 379 amino acid containing signaling protein that acts as an important component of innate immune signaling. This signaling protein is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. STING may have translocon function, the translocon possibly being able to influence the induction of type I interferons and is also involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II) thus facilitating the detection of intracellular viral RNA species as well as B-form DNA and mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Generally seen in endoplasmic reticulum membrane, cell membrane and mitochondrion outer membrane, it is ubiquitously expressed in most of tissues.
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Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; hMITA; hSTING; Mediator of IRF3 activation; MITA; mitochondrial mediator of IRF3 activation; mitochondrial transmembrane protein 173; MMITA; MPYS; mSTING; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; NET23; poSTING; rSTING; Stimulator of interferon genes protein; STING; Transmembrane protein 173; transmembrane protein 173-like
Gene Aliases: 2610307O08Rik; BOS_8183; ERIS; hMITA; hSTING; MITA; MPYS; NET23; RGD1562552; SAVI; STING; TMEM173