Immunogen sequence: YSNSIYELLE NGQRAGTCVL EYATPLQTLF AMSQYSQAGF SREDRLEQAK LFCQTLEDIL ADAPESQNNC R
MPYS is a recently identified plasma membrane tetraspanner that is associated with major histocompatibility complex class II (MHC-II) and mediates its transduction of apoptotic signals. It has also been found to be associated with VISA, a mitochondrial protein that acts as an adaptor in virus-triggered signaling. MPYS also interacts with IRF3 and recruits the kinase TBK1 to the VISA-associated complex, acting as a critical mediator of virus-triggered IRF3 activation and interferon (IFN) expression. It is thought that the binding of nucleic acid to the innate immune protein RIG-I causes complex formation between RIG-I, VISA, and MPYS. This complex then recruits TBK1 to phosphorylate IRF3 which then directly activates IFN transcription. At least three isoforms of MPYS are known to exist.
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Protein Aliases: endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; ERIS; FLJ38577; hMITA; hSTING; Mediator of IRF3 activation; mitochondrial mediator of IRF3 activation; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner; NET23; Stimulator of interferon genes protein; Transmembrane protein 173
Gene Aliases: ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; TMEM173
UniProt ID: (Human) Q86WV6
Entrez Gene ID: (Human) 340061