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Proteintech
STK25 Polyclonal Antibody
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Product Details
25821-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STK25 Fusion Protein Ag22964 (323-426 aa encoded by BC015793)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PTIRPSPHS KLHKGTALHS SQKPAEPVKR QPRSQCLSTL VRPVFGELKE KHEQSGGSVG ALEELENAFS LAEESCPGIS DKLMVHLVER VQRFSHNRNH LTSTR (323-426 aa encoded by BC015793)
Target Information
STK25 (YSK1) is a serine/threonine kinase that belongs to the GCK family of kinases. It has been implicated as an upstream regulator of MAP kinase signaling pathways. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The STE group (homologs of yeast Sterile 7, 11, 20 kinases) consists of 50 kinases related to the mitogen-activated protein kinase (MAPK) cascade families (Ste7/MAP2K, Ste11/MAP3K, and Ste20/MAP4K). MAP kinase cascades, consisting of a MAPK and one or more upstream regulatory kinases (MAPKKs) have been best characterized in the yeast pheromone response pathway. Pheromones bind to Ste cell surface receptors and activate yeast MAPK pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: serine/threonine kinase 25 (STE20 homolog, yeast); serine/threonine kinase 25 (Ste20, yeast homolog); Serine/threonine-protein kinase 25; SOK-1; Ste20, yeast homolog; Ste20-like kinase; ste20/oxidant stress response kinase 1; Sterile 20/oxidant stress-response kinase 1; unnamed protein product; Yeast Sps1/Ste20-related kinase 1
Gene Aliases: 1500019J11Rik; AU018434; C86992; SOK1; Ste20-like; STK25; YSK1
UniProt ID: (Human) O00506, (Mouse) Q9Z2W1
Entrez Gene ID: (Human) 10494, (Rat) 373542, (Mouse) 59041
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein homodimerization activity
metal ion binding
protein serine kinase activity
receptor signaling protein serine/threonine kinase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
apoptotic process
establishment or maintenance of cell polarity
signal transduction by protein phosphorylation
positive regulation of stress-activated MAPK cascade
intracellular signal transduction
intrinsic apoptotic signaling pathway in response to hydrogen peroxide
response to hydrogen peroxide
regulation of cell differentiation
protein autophosphorylation
positive regulation of axonogenesis
Golgi localization
establishment of Golgi localization
Golgi reassembly
response to oxidative stress
signal transduction
axonogenesis
cellular response to oxidative stress
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
activation of protein kinase activity
regulation of apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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