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STK3/MST-2 Polyclonal Antibody

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STK3/MST-2 Polyclonal Antibody

Product Details

MST2-101AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

ELISA (ELISA)

1:10,000
-

Immunoprecipitation (IP)

1:50-1:250
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide taken within amino acid region 400-450 on mouse Mammalian STE20-like protein kinase 2 / STE20-like kinase MST2 / STK3.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1.5 mg/mL

Purification

Affinity chromatography

Storage buffer

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

STK3 (MST2) is a STE kinase family member that acts upstream of the MAP kinase signaling pathways, and is known to be activated by the proapoptotic stimuli staurosporine and FAS ligand. STK3 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: epididymis secretory sperm binding protein; hippo homolog; KB-1458E12.1; Mammalian STE20-like protein kinase 2; MST-2; protein kinase homolog; serine/threonine kinase 3 (STE20 homolog, yeast); serine/threonine kinase 3 (Ste20, yeast homolog); Serine/threonine-protein kinase 3; Serine/threonine-protein kinase Krs-1; STE20-like kinase MST2; unnamed protein product

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Gene Aliases: 0610042I06Rik; KRS1; Mess1; MST; MST2; Mst3; Ste20; STK3

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UniProt ID: (Human) Q13188, (Rat) O54748, (Mouse) Q9JI10

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Entrez Gene ID: (Human) 6788, (Rat) 65189, (Mouse) 56274

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Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding kinase activity transferase activity identical protein binding protein serine/threonine kinase activator activity metal ion binding protein serine kinase activity transcription regulator activator activity receptor signaling protein serine/threonine kinase activity MAP kinase kinase kinase activity transferase activity, transferring phosphorus-containing groups non-receptor serine/threonine protein kinase
Process(es)
neural tube formation endocardium development protein phosphorylation protein import into nucleus apoptotic process signal transduction JNK cascade central nervous system development cell proliferation negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors regulation of gene expression organ growth hippo signaling positive regulation of hippo signaling intracellular signal transduction positive regulation of apoptotic process regulation of MAPK cascade protein kinase B signaling positive regulation of fat cell differentiation positive regulation of JNK cascade negative regulation of organ growth epithelial cell proliferation negative regulation of epithelial cell proliferation protein stabilization protein tetramerization centrosome separation positive regulation of protein kinase B signaling canonical Wnt signaling pathway primitive hemopoiesis cell differentiation involved in embryonic placenta development regulation of cell differentiation involved in embryonic placenta development protein localization to centrosome negative regulation of canonical Wnt signaling pathway hepatocyte apoptotic process positive regulation of extrinsic apoptotic signaling pathway via death domain receptors signal transduction by protein phosphorylation positive regulation of protein binding positive regulation of sequence-specific DNA binding transcription factor activity MAPK cascade activation of MAPKK activity regulation of mitotic cell cycle phosphorylation stress-activated protein kinase signaling cascade
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