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Invitrogen
STK36 Polyclonal Antibody
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FIGURE: 1 / 3
STK36 Antibody (PA5-106734) in IHC (P)
Immunohistochemistry analysis of STK36 in rat testis tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with STK36 polyclonal antibody (Product # PA5-106734) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-106734
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human STK36(Accession Q9NRP7), corresponding to amino acid residues D386-A436.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total STK36.
Target Information
Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Fused homolog; serine/threonine kinase 36 (fused homolog, Drosophila); Serine/threonine-protein kinase 36; stk36; testicular tissue protein Li 188; unnamed protein product
Gene Aliases: 1700112N14Rik; B930045J24; CILD46; FU; Fused; KIAA1278; mKIAA1278; STK36
UniProt ID: (Human) Q9NRP7, (Mouse) Q69ZM6
Entrez Gene ID: (Human) 27148, (Rat) 301516, (Mouse) 269209
nucleotide binding
transcription corepressor binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
transferase activity
metal ion binding
protein serine kinase activity
transcription factor binding
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein modifying enzyme
epithelial cilium movement
protein phosphorylation
microtubule-based process
smoothened signaling pathway
brain development
post-embryonic development
cell projection organization
axoneme assembly
positive regulation of smoothened signaling pathway
regulation of sequence-specific DNA binding transcription factor activity
cilium morphogenesis
positive regulation of hh target transcription factor activity
cilium assembly
multicellular organism development
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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