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Proteintech
STK38 Polyclonal Antibody
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Product Details
11105-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STK38 Fusion Protein Ag1559 (116-465 aa encoded by BC012085)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes the C-terminal of STK38.
Immunogen sequence: AMKILRKAD MLEKEQVGHI RAERDILVEA DSLWVVKMFY SFQDKLNLYL IMEFLPGGDM MTLLMKKDTL TEEETQFYIA ETVLAIDSIH QLGFIHRDIK PDNLLLDSKG HVKLSDFGLC TGLKKAHRTE FYRNLNHSLP SDFTFQNMNS KRKAETWKRN RRQLAFSTVG TPDYIAPEVF MQTGYNKLCD WWSLGVIMYE MLIGYPPFCS ETPQETYKKV MNWKETLTFP PEVPISEKAK DLILRFCCEW EHRIGAPGVE EIKSNSFFEG VDWEHIRERP AAISIEIKSI DDTSNFDEFP ESDILKPTVA TSNHPETDYK NKDWVFINYT YKRFEGLTAR GAIPSYMKAA K (116-465 aa encoded by BC012085)
Target Information
STK38 (also known as NDR) or Nuclear Dbf2-related protein is a serine/threonine kinase in the subgroup of the AGC kinase family that is regulated by Mob proteins. Fas and TNFα receptor stimulation activates human STK38 by promoting phosphorylation at the hydrophobic motif. NDR acts as a novel pro-apoptotic kinase, and is a key member of the RASSF1A/MST1 signaling cascade. STK38 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells. STK38 is incorporated into the HIV-1 particles and is cleaved by the HIV-1 protease. STK38-driven centrosome duplication requires Cdk2 activity, and Cdk2-induced centrosome amplification is affected upon reduction of STK38 activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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