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Product Details
22245-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STK4/MST1 Fusion Protein Ag17738 (383-451 aa encoded by BC093768)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.56 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: RRDETMQPA KPSFLEYFEQ KEKENQINSF GKSVPGPLKN SSDWKIPQDG DYEFLKSWTV EDLQKRLLAL (383-451 aa encoded by BC093768)
Target Information
STK4 (MST1) is a serine/threonine kinase which may be involved in apoptosis. It is possible that this protein induces the chromatin condensation observed in this process. STK4 is a stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. It is a key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: EC 2.7.11.1; kinase MST1; kinase responsive to stress 2; Mammalian STE20-like protein kinase 1; mammalian sterile 20-like 1; MST-1; Serine/threonine-protein kinase 4; Serine/threonine-protein kinase Krs-2; STE20-like kinase MST1; sterile 20-like kinase 1; TIIAC; Yeast Sps1/Ste20-related kinase 3
Gene Aliases: AI447339; AU020804; Kas-2; KRS2; MST1; STK4; YSK3
UniProt ID: (Human) Q13043, (Mouse) Q9JI11
Entrez Gene ID: (Human) 6789, (Rat) 311622, (Mouse) 58231
magnesium ion binding
protein kinase activity
protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
transcription factor binding
identical protein binding
protein homodimerization activity
protein serine/threonine kinase activator activity
protein dimerization activity
nucleotide binding
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
metal ion binding
non-receptor serine/threonine protein kinase
cell morphogenesis
patterning of blood vessels
neural tube formation
positive regulation of protein phosphorylation
endocardium development
protein phosphorylation
apoptotic process
signal transduction
central nervous system development
negative regulation of cell proliferation
peptidyl-serine phosphorylation
signal transduction by protein phosphorylation
keratinocyte differentiation
positive regulation of protein binding
positive regulation of peptidyl-serine phosphorylation
hippo signaling
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of fat cell differentiation
negative regulation of organ growth
protein autophosphorylation
protein stabilization
primitive hemopoiesis
cell differentiation involved in embryonic placenta development
regulation of cell differentiation involved in embryonic placenta development
positive regulation of protein serine/threonine kinase activity
negative regulation of canonical Wnt signaling pathway
hepatocyte apoptotic process
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
MAPK cascade
activation of MAPKK activity
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
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