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Invitrogen
STOML2 Polyclonal Antibody
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FIGURE: 1 / 2
STOML2 Antibody (PA5-87867) in IHC (P)
Immunohistochemistry analysis of STOML2 in paraffin-embedded human breast cancer using. Samples were incubated with STOML2 Polyclonal antibody (Product # PA5-87867) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-87867
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 29-356 of human STOML2 (NP_0384701)
Conjugate
Form
Liquid
Concentration
1.95 mg/mL
Amount
195 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SSGLPRNTVV LFVPQQEAWV VERMGRFHRI LEPGLNILIP VLDRIRYVQS LKEIVINVPE QSAVTLDNVT LQIDGVLYLR IMDPYKASYG VEDPEYAVTQ LAQTTMRSEL GKLSLDKVFR ERESLNASIV DAINQAADCW GIRCLRYEIK DIHVPPRVKE SMQMQVEAER RKRATVLESE GTRESAINVA EGKKQAQILA SEAEKAEQIN QAAGEASAVL AKAKAKAEAI RILAAALTQH NGDAAASLTV AEQYVSAFSK LAKDSNTILL PSNPGDVTSM VAQAMGVYGA LTKAPVPGTP DSLSSGSSRD VQGTDASLDE ELDRVKMS; Positive Samples: U-87MG, A375, A-549, B-cell, Mouse liver, Mouse kidney, Rat liver, Rat thymus; Cellular Location: Cell membrane, Membrane raft, Mitochondrion inner membrane, Mitochondrion intermembrane space, Peripheral membrane protein
Target Information
Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EPB72-like 2; EPB72-like protein 2; Paraprotein target 7; Paratarg-7; SLP-2; stomatin (EPB72)-like 2; stomatin-like protein 2; Stomatin-like protein 2, mitochondrial; unnamed protein product
Gene Aliases: 0610038F01Rik; HSPC108; MSLP2; SLP-2; SLP2; STOML2
UniProt ID: (Human) Q9UJZ1, (Mouse) Q99JB2, (Rat) Q4FZT0
Entrez Gene ID: (Human) 30968, (Mouse) 66592, (Rat) 298203
cellular calcium ion homeostasis
mitochondrion organization
lipid localization
positive regulation of interleukin-2 production
mitochondrial protein processing
CD4-positive, alpha-beta T cell activation
mitochondrial ATP synthesis coupled proton transport
T cell receptor signaling pathway
protein oligomerization
stress-induced mitochondrial fusion
mitochondrial calcium ion transport
positive regulation of mitochondrial membrane potential
interleukin-2 production
mitochondrion localization
positive regulation of mitochondrial DNA replication
positive regulation of cardiolipin metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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