Search
Proteintech
STRAP Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
18277-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
STRAP Fusion Protein Ag13085 (1-350 aa encoded by BC000162)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAMRQTPLT CSGHTRPVVD LAFSGITPYG YFLISACKDG KPMLRQGDTG DWIGTFLGHK GAVWGATLNK DATKAATAAA DFTAKVWDAV SGDELMTLAH KHIVKTVDFT QDSNYLLTGG QDKLLRIYDL NKPEAEPKEI SGHTSGIKKA LWCSEDKQIL SADDKTVRLW DHATMTEVKS LNFNMSVSSM EYIPEGEILV ITYGRSIAFH SAVSLDPIKS FEAPATINSA SLHPEKEFLV AGGEDFKLYK YDYNSGEELE SYKGHFGPIH CVRFSPDGEL YASGSEDGTL RLWQTVVGKT YGLWKCVLPE EDSGELAKPK IGFPETTEEE LEEIASENSD CIFPSAPDVK A (1-350 aa encoded by BC000162)
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MAP activator with WD repeats; MAPK activator with WD repeats; mitogen-activated protein kinase activator with WD repeats; Serine-threonine kinase receptor-associated protein; unnamed protein product; UNR-interacting protein; WD-40 repeat protein PT-WD
Gene Aliases: AW557906; C78091; C79202; MAWD; PT-WD; STRAP; UNRIP
UniProt ID: (Human) Q9Y3F4, (Mouse) Q9Z1Z2, (Rat) Q5XIG8
Entrez Gene ID: (Human) 11171, (Mouse) 20901, (Rat) 297699
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
spliceosomal snRNP assembly
mRNA splicing, via spliceosome
mRNA processing
RNA splicing
ribonucleoprotein complex assembly
neuron differentiation
maintenance of gastrointestinal epithelium
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
negative regulation of epithelial cell proliferation
negative regulation of pathway-restricted SMAD protein phosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support