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Invitrogen
STRAP Polyclonal Antibody
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Product Details
PA5-96486
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human STRAP (NP_0091093)
Conjugate
Form
Liquid
Concentration
0.64 mg/mL
Amount
64 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAMRQTPLTC SGHTRPVVDL AFSGITPYGY FLISACKDGK PMLRQGDTGD WIGTFLGHKG AVWGATLNKD ATKAATAAAD FTAKVWDAVS GDELMTLAHK HIVKTVDFTQ DSNYLLTGGQ DKLLRIYDLN KPEAEPKEIS GHTSGIKKAL WCSEDKQILS ADDKTVRLWD HATMTEVKSL NFNMSVSSME YIPEGEILVI TYGRSIAFHS AVSLDPIKSF EAPATINSAS LHPEKEFLVA GGEDFKLYKY DYNSGEELES YKGHFGPIHC VRFSPDGELY ASGSEDGTLR LWQTVVGKTY GLWKCVLPEE DSGELAKPKI GFPETTEEEL EEIASENSDC IFPSAPDVKA; Positive Samples: Jurkat, HeLa, SW480, A-549, Mouse brain, Mouse lung, Mouse testis; Cellular Location: Cytoplasm, Nucleus
Target Information
STRAP is a 350 amino acid MAP activator with WD-40 repeats that is localized both in the cytoplasm and the nucleus. It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP activator with WD repeats; MAPK activator with WD repeats; mitogen-activated protein kinase activator with WD repeats; Serine-threonine kinase receptor-associated protein; unnamed protein product; UNR-interacting protein; WD-40 repeat protein PT-WD
Gene Aliases: AW557906; C78091; C79202; MAWD; PT-WD; STRAP; UNRIP
UniProt ID: (Human) Q9Y3F4, (Mouse) Q9Z1Z2, (Rat) Q5XIG8
Entrez Gene ID: (Human) 11171, (Mouse) 20901, (Rat) 297699
negative regulation of transcription from RNA polymerase II promoter
alternative mRNA splicing, via spliceosome
spliceosomal snRNP assembly
mRNA splicing, via spliceosome
mRNA processing
RNA splicing
ribonucleoprotein complex assembly
neuron differentiation
maintenance of gastrointestinal epithelium
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of epithelial cell migration
negative regulation of epithelial to mesenchymal transition
negative regulation of epithelial cell proliferation
negative regulation of pathway-restricted SMAD protein phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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