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Invitrogen
STS1 Polyclonal Antibody
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Product Details
PA5-96591
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human UBASH3B (NP_1162622)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MAQYGHPSPL GMAAREELYS KVTPRRNRQQ RPGTIKHGSA LDVLLSMGFP RARAQKALAS TGGRSVQAAC DWLFSHVGDP FLDDPLPREY VLYLRPTGPL AQKLSDFWQQ SKQICGKNKA HNIFPHITLC QFFMCEDSKV DALGEALQTT VSRWKCKFSA PLPLELYTSS NFIGLFVKED SAEVLKKFAA DFAAEAASKT EVHVEPHKKQ LHVTLAYHFQ ASHLPTLEKL AQNIDVKLGC DWVATIFSRD IRFANHETLQ VIYPYTPQND DELELVPGDF IFMSPMEQTS TSEGWIYGTS; Positive Samples: SW620, SKOV3, Mouse brain, Mouse spleen, Mouse lung, Rat brain; Cellular Location: Cytoplasm, Nucleus
Target Information
Sts1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cbl-interacting protein p70; Cbl-interacting protein Sts-1; MGC15437; nm23-phosphorylated unknown substrate; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate; STS-1; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2; Ubiquitin-associated and SH3 domain-containing protein B; unnamed protein product
Gene Aliases: 2810457I06Rik; BB125008; KIAA1959; p70; RGD1310357; STS-1; STS1; TULA-2; TULA2; UBASH3B
UniProt ID: (Human) Q8TF42, (Mouse) Q8BGG7
Entrez Gene ID: (Human) 84959, (Mouse) 72828, (Rat) 315579
negative regulation of protein kinase activity
negative regulation of signal transduction
peptidyl-tyrosine dephosphorylation
negative regulation of osteoclast differentiation
negative regulation of bone resorption
regulation of release of sequestered calcium ion into cytosol
negative regulation of platelet aggregation
signal transduction
platelet activation
collagen-activated tyrosine kinase receptor signaling pathway
collagen-activated signaling pathway
regulation of osteoclast differentiation
platelet aggregation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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