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STXBP2 Polyclonal Antibody

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Antibody Testing Data (9)

STXBP2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 9

STXBP2 Antibody (15312-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human lung cancer using 15312-1-AP (STXBP2 antibody) at dilution of 1:50 (under 40x lens).

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Product Details

15312-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

STXBP2 Fusion Protein Ag7537 (241-590 aa encoded by BC002869)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.21 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: LHELTFQAM AYDLLDIEQD TYRYETTGLS EAREKAVLLD EDDDLWVELR HMHIADVSKK VTELLRTFCE SKRLTTDKAN IKDLSQILKK MPQYQKELNK YSTHLHLADD CMKHFKGSVE KLCSVEQDLA MGSDAEGEKI KDSMKLIVPV LLDAAVPAYD KIRVLLLYIL LRNGVSEENL AKLIQHANVQ AHSSLIRNLE QLGGTVTNPG GSGTSSRLEP RERMEPTYQL SRWTPVIKDV MEDAVEDRLD RNLWPFVSDP APTASSQAAV SARFGHWHKN KAGIEARAGP RLIVYVMGGV AMSEMRAAYE VTRATEGKWE VLIGSSHILT PTRFLDDLKA LDKKLEDIAL P (241-590 aa encoded by BC002869)

Target Information

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

The septin cytoskeleton regulates natural killer cell lytic granule release.

The Journal of cell biology

Phatarpekar PV,Overlee BL,Leehan A,Wilton KM,Ham H,Billadeau DD

Mon Nov 02 00:00:00 EST 2020

SNAP25/syntaxin4/VAMP2/Munc18-1 Complexes in Spinal Dorsal Horn Contributed to Inflammatory Pain.

Neuroscience

Duan XL,Guo Z,He YT,Li YX,Liu YN,Bai HH,Li HL,Hu XD,Suo ZW

Sun Mar 01 00:00:00 EST 2020

Molecular analysis of the novel L243R mutation in STXBP2 reveals impairment of degranulation activity.

International journal of hematology

Viñas-Giménez L,Donadeu L,Alsina L,Rincón R,de la Campa EÁ,Esteve-Sole A,Català A,Colobran R,de la Cruz X,Sayós J,Martínez-Gallo M

Sun Mar 01 00:00:00 EST 2020

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 EDT 2014

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.

The Journal of experimental medicine

Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT

Mon Jun 02 00:00:00 EDT 2014

An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2.

Frontiers in immunology

Müller ML,Chiang SC,Meeths M,Tesi B,Entesarian M,Nilsson D,Wood SM,Nordenskjöld M,Henter JI,Naqvi A,Bryceson YT

Tue Jan 14 00:00:00 EST 2014

Bioinformatics

Protein Aliases: Munc18-2; MUSEC1; Protein unc-18 homolog 2; Protein unc-18 homolog B; syntaxin binding protein Munc18-2; Syntaxin-binding protein 2; unc-18 homolog 2; Unc-18B; Unc18-2

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Gene Aliases: C79054; FHL5; Hunc18b; Munc-18-2; Munc-18b; MUNC18-2; Munc18b; muSec1; pp10122; STXBP2; Sxtbp2; Sxtp2; UNC18-2; UNC18B

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UniProt ID: (Human) Q15833, (Mouse) Q64324

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Entrez Gene ID: (Human) 6813, (Mouse) 20911

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Function(s)

protein binding syntaxin-1 binding syntaxin-3 binding syntaxin binding membrane trafficking regulatory protein

Process(es)

leukocyte mediated cytotoxicity vesicle docking involved in exocytosis protein transport regulation of mast cell degranulation neutrophil degranulation transport exocytosis vesicle-mediated transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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STXBP2 Polyclonal Antibody

STXBP2 Antibody (15312-1-AP) in IHC (P)

Product Details

15312-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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