Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: MIGVSFEEA KSIITGAKLS TRLESAWEIA FIRQKSDNIQ PENLSCTSLI EASGEYGPQA STLSLFSSPP EILIPKTSST PKTNNDILSS CEIKTGYNKT VQIPITSENS TVGLSNTDVA SAWTENYGLQ EKISLNPSVR FKAEKLEMAL NYLGIQPTKE QHQALRQQVQ ADSKGTVSFG DFVQVARNLF CLQLDEVNVG AHEISNILDS QLLPCDSSEA DEMERLKCER DDALKEVNTL KWPGQN (1-245 aa encoded by B C041485)
STXBP4 plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. STXBP4 inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. STXBP4 may also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ16496; MGC149829; MGC50337; STX4-interacting protein; syntaxin 4 interacting protein; Syntaxin 4-interacting protein; Syntaxin-binding protein 4
Gene Aliases: 6030470M02Rik; STXBP4; Synip
UniProt ID: (Human) Q6ZWJ1, (Mouse) Q9WV89
Entrez Gene ID: (Human) 252983, (Mouse) 20913, (Rat) 303443
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