Immunogen sequence: MLCIAGVSA HVIIYRFSKQ EVITEVIPML EVRLLYEIND VETPEGEQPP PLPTPVGGSN PQPIPPQSHP STSSSSSDGL RDNVPCLKVK NSPLKQS (515-610 aa encoded by BC113382 )
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced transcript variants encoding different isoforms have been identified.
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Protein Aliases: FLJ30922; L Nbla04300; Lethal(2) giant larvae protein homolog 3; MGC141942; MGC141968; putative protein product of Nbla04300; RP11-361F15.4; STXB5; syntaxin binding protein 5 (tomosyn); Syntaxin-binding protein 5; tomosyn; Tomosyn-1
Gene Aliases: LGL3; LLGL3; Nbla04300; STXBP5
Molecular Function: membrane trafficking regulatory protein