Immunogen sequence: SGPQGIAPVP PPRDLSWEAG HGGNVALPLK ETSVENFLGA TTPALAKLQV PREQLSEVLE QICSGSCGPI FRANMNTGDP SKPKSVILKA LKEPAGLHEV QDFLGRIQFH QYLGKHKNLV QLEGCCTEKL PLYM
STYK1, a probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways. It is widely expressed; highly expressed in brain, placenta and prostate. STYK1 is expressed in tumor cells such as hepatoma cells LO2, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K562, but not in other tumor cells such as epidermoid carcinoma.
Protein Aliases: DKFZp761P1010; Novel oncogene with kinase domain; Protein PK-unique; Serine/threonine/tyrosine kinase 1; Tyrosine-protein kinase STYK1
Gene Aliases: NOK; STYK1; SuRTK106
UniProt ID: (Human) Q6J9G0
Entrez Gene ID: (Human) 55359
Molecular Function: transmembrane signal receptor