Immunogen sequence: TEELHSAQQW NGQGILELLR TVPIAGGPWL ITDMRRGETI FEIDPHLQER VDKGIETDGS NLSGVSAKCA WDDLSRPPED DEDSRSICIG TQPRRLSGKD TEQIRETLRR GLEINSKPVL PPINPQRQNG LAHDRAPSRK DSLESDSSTA
The Hedgehog signaling pathway plays an important role in early human development. The pathway is a signaling cascade that plays a role in pattern formation and cellular proliferation during development. This gene encodes a negative regulator of the hedgehog signaling pathway. Defects in this gene are a cause of medulloblastoma. Alternative splicing results in multiple transcript variants.
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Protein Aliases: PRO1280; SUFUH; SUFUXL; Suppressor of fused homolog
Gene Aliases: PRO1280; SUFU; SUFUH; SUFUXL; UNQ650/PRO1280
UniProt ID: (Human) Q9UMX1
Entrez Gene ID: (Human) 51684