Heparan sulfate 6-O-endosulfatases, such as Sulfatase 2, selectively remove 6-O-sulfate groups from heparan sulfate. Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 ).
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Protein Aliases: DKFZp313E091; Extracellular sulfatase Sulf-2; FLJ44488; FLJ90554; hSulf-2; MGC126411; OTTHUMP00000031223; RP5-1049G16.1
Gene Aliases: HSULF-2; KIAA1247; SULF2; UNQ559/PRO1120
UniProt ID: (Human) Q8IWU5
Entrez Gene ID: (Human) 55959
Molecular Function: hydrolase