Proteintech

SULT4A1 Polyclonal Antibody

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SULT4A1 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 12578-1-AP (SULT4A1 Antibody) at dilution of 1:2000 incubated at room temperature for 1.5 hours.

SULT4A1 Antibody in Immunoprecipitation (IP) — IP result of anti-SULT4A1 (IP:12578-1-AP, 4ug; Detection:12578-1-AP 1:300) with mouse brain tissue lysate 4000ug.

Product Details

12578-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

Assay-dependent

View 3 publications 3 publications

Immunocytochemistry (ICC/IF)

View 4 publications 4 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SULT4A1 Fusion Protein Ag3271 (1-284 aa encoded by BC022459)

View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

Immunogen sequence: MAESEAETP STPGEFESKY FEFHGVRLPP FCRGKMEEIA NFPVRPSDVW IVTYPKSGTS LLQEVVYLVS QGADPDEIGL MNIDEQLPVL EYPQPGLDII KELTSPRLIK SHLPYRFLPS DLHNGDSKVI YMARNPKDLV VSYYQFHRSL RTMSYRGTFQ EFCRRFMNDK LGYGSWFEHV QEFWEHRMDS NVLFLKYEDM HRDLVTMVEQ LARFLGVSCD KAQLEALTEH CHQLVDQCCS AEALPVGRGR VGLWKDIFTV SMNEKFDLVY KQKMGKCDLT FDFYL (1-284 aa encoded by BC022459)

Target Information

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure(number and length of exons) is similar among family members. SULT4A1 isoforms a and b are selectively expressed in brain tissue. Isoform a is the predominant of the two isoforms of this protein. Isoform b includes an alternate segment, compared to isoform a, that causes a frameshift. The resulting protein (isoform b) has a distinct and shorter C-terminus when compared to isoform a.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress.

Scientific reports

Brettrager EJ,Meehan AW,Falany CN,van Waardenburg RCAM

Mon Jan 31 00:00:00 EST 2022

SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Culotta L,Scalmani P,Vinci E,Terragni B,Sessa A,Broccoli V,Mantegazza M,Boeckers T,Verpelli C

Wed Sep 09 00:00:00 EDT 2020

SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Culotta L,Scalmani P,Vinci E,Terragni B,Sessa A,Broccoli V,Mantegazza M,Boeckers T,Verpelli C

Wed Sep 09 00:00:00 EDT 2020

SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Culotta L,Scalmani P,Vinci E,Terragni B,Sessa A,Broccoli V,Mantegazza M,Boeckers T,Verpelli C

Wed Sep 09 00:00:00 EDT 2020

SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Culotta L,Scalmani P,Vinci E,Terragni B,Sessa A,Broccoli V,Mantegazza M,Boeckers T,Verpelli C

Wed Sep 09 00:00:00 EDT 2020

Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.

Drug metabolism and disposition: the biological fate of chemicals

Idris M,Mitchell DJ,Gordon R,Sidharthan NP,Butcher NJ,Minchin RF

Fri May 01 00:00:00 EDT 2020

Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function.

Drug metabolism and disposition: the biological fate of chemicals

Idris M,Mitchell DJ,Gordon R,Sidharthan NP,Butcher NJ,Minchin RF

Fri May 01 00:00:00 EDT 2020

SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.

Drug metabolism and disposition: the biological fate of chemicals

Hossain MI,Marcus JM,Lee JH,Garcia PL,Gagné JP,Poirier GG,Falany CN,Andrabi SA

Sun Sep 01 00:00:00 EDT 2019

SULT4A1 Protects Against Oxidative-Stress Induced Mitochondrial Dysfunction in Neuronal Cells.

Drug metabolism and disposition: the biological fate of chemicals

Hossain MI,Marcus JM,Lee JH,Garcia PL,Gagné JP,Poirier GG,Falany CN,Andrabi SA

Sun Sep 01 00:00:00 EDT 2019

The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation.

Drug metabolism and disposition: the biological fate of chemicals

Idris M,Butcher NJ,Minchin RF

Fri Mar 01 00:00:00 EST 2019

The MBNL/CELF Splicing Factors Regulate Cytosolic Sulfotransferase 4A1 Protein Expression during Cell Differentiation.

Drug metabolism and disposition: the biological fate of chemicals

Idris M,Butcher NJ,Minchin RF

Fri Mar 01 00:00:00 EST 2019

Generation and Characterization of SULT4A1 Mutant Mouse Models.

Drug metabolism and disposition: the biological fate of chemicals

Garcia PL,Hossain MI,Andrabi SA,Falany CN

Mon Jan 01 00:00:00 EST 2018

Generation and Characterization of SULT4A1 Mutant Mouse Models.

Drug metabolism and disposition: the biological fate of chemicals

Garcia PL,Hossain MI,Andrabi SA,Falany CN

Mon Jan 01 00:00:00 EST 2018

Generation and Characterization of SULT4A1 Mutant Mouse Models.

Drug metabolism and disposition: the biological fate of chemicals

Garcia PL,Hossain MI,Andrabi SA,Falany CN

Mon Jan 01 00:00:00 EST 2018

Generation and Characterization of SULT4A1 Mutant Mouse Models.

Drug metabolism and disposition: the biological fate of chemicals

Garcia PL,Hossain MI,Andrabi SA,Falany CN

Mon Jan 01 00:00:00 EST 2018

From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

Biochimica et biophysica acta

Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A

Tue Dec 01 00:00:00 EST 2015

From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

Biochimica et biophysica acta

Colombrita C,Onesto E,Buratti E,de la Grange P,Gumina V,Baralle FE,Silani V,Ratti A

Tue Dec 01 00:00:00 EST 2015

Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination.

PloS one

Sidharthan NP,Butcher NJ,Mitchell DJ,Minchin RF

Tue Oct 20 00:00:00 EDT 2015

Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination.

PloS one

Sidharthan NP,Butcher NJ,Mitchell DJ,Minchin RF

Tue Oct 20 00:00:00 EDT 2015

Expression of the orphan cytosolic sulfotransferase SULT4A1 and its major splice variant in human tissues and cells: dimerization, degradation and polyubiquitination.

PloS one

Sidharthan NP,Butcher NJ,Mitchell DJ,Minchin RF

Tue Oct 20 00:00:00 EDT 2015

Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish.

Drug metabolism and disposition: the biological fate of chemicals

Crittenden F,Thomas HR,Parant JM,Falany CN

Wed Jul 01 00:00:00 EDT 2015

Activity Suppression Behavior Phenotype in SULT4A1 Frameshift Mutant Zebrafish.

Drug metabolism and disposition: the biological fate of chemicals

Crittenden F,Thomas HR,Parant JM,Falany CN

Wed Jul 01 00:00:00 EDT 2015

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 EDT 2013

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 EDT 2013

Evaluation of resveratrol sensitivities and metabolic patterns in human and rat glioblastoma cells.

Cancer chemotherapy and pharmacology

Sun Z,Shi S,Li H,Shu XH,Chen XY,Kong QY,Liu J

Fri Nov 01 00:00:00 EDT 2013

Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells.

The FEBS journal

Sun Z,Li H,Shu XH,Shi H,Chen XY,Kong QY,Wu ML,Liu J

Sun Jul 01 00:00:00 EDT 2012

Distinct sulfonation activities in resveratrol-sensitive and resveratrol-insensitive human glioblastoma cells.

The FEBS journal

Sun Z,Li H,Shu XH,Shi H,Chen XY,Kong QY,Wu ML,Liu J

Sun Jul 01 00:00:00 EDT 2012

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one

Shu XH,Li H,Sun XX,Wang Q,Sun Z,Wu ML,Chen XY,Li C,Kong QY,Liu J

Tue Apr 10 00:00:00 EDT 2012

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one

Shu XH,Li H,Sun XX,Wang Q,Sun Z,Wu ML,Chen XY,Li C,Kong QY,Liu J

Tue Apr 10 00:00:00 EDT 2012

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one

Shu XH,Li H,Sun XX,Wang Q,Sun Z,Wu ML,Chen XY,Li C,Kong QY,Liu J

Tue Apr 10 00:00:00 EDT 2012

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one

Shu XH,Li H,Sun XX,Wang Q,Sun Z,Wu ML,Chen XY,Li C,Kong QY,Liu J

Tue Apr 10 00:00:00 EDT 2012

Metabolic patterns and biotransformation activities of resveratrol in human glioblastoma cells: relevance with therapeutic efficacies.

PloS one

Shu XH,Li H,Sun XX,Wang Q,Sun Z,Wu ML,Chen XY,Li C,Kong QY,Liu J

Tue Apr 10 00:00:00 EDT 2012

Phosphorylation/dephosphorylation of human SULT4A1: role of Erk1 and PP2A.

Biochimica et biophysica acta

Mitchell DJ,Butcher NJ,Minchin RF

Sat Jan 01 00:00:00 EST 2011

Phosphorylation/dephosphorylation of human SULT4A1: role of Erk1 and PP2A.

Biochimica et biophysica acta

Mitchell DJ,Butcher NJ,Minchin RF

Sat Jan 01 00:00:00 EST 2011

Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.

Molecular pharmacology

Butcher NJ,Mitchell DJ,Burow R,Minchin RF

Wed Sep 01 00:00:00 EDT 2010

Regulation of mouse brain-selective sulfotransferase sult4a1 by cAMP response element-binding protein and activating transcription factor-2.

Molecular pharmacology

Butcher NJ,Mitchell DJ,Burow R,Minchin RF

Wed Sep 01 00:00:00 EDT 2010

Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.

Biochemical pharmacology

Shu XH,Li H,Sun Z,Wu ML,Ma JX,Wang JM,Wang Q,Sun Y,Fu YS,Chen XY,Kong QY,Liu J

Sat May 15 00:00:00 EDT 2010

Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.

Biochemical pharmacology

Shu XH,Li H,Sun Z,Wu ML,Ma JX,Wang JM,Wang Q,Sun Y,Fu YS,Chen XY,Kong QY,Liu J

Sat May 15 00:00:00 EDT 2010

Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.

Biochemical pharmacology

Shu XH,Li H,Sun Z,Wu ML,Ma JX,Wang JM,Wang Q,Sun Y,Fu YS,Chen XY,Kong QY,Liu J

Sat May 15 00:00:00 EDT 2010

Identification of metabolic pattern and bioactive form of resveratrol in human medulloblastoma cells.

Biochemical pharmacology

Shu XH,Li H,Sun Z,Wu ML,Ma JX,Wang JM,Wang Q,Sun Y,Fu YS,Chen XY,Kong QY,Liu J

Sat May 15 00:00:00 EDT 2010

Bioinformatics

Protein Aliases: Brain sulfotransferase-like protein; hBR-STL; mBR-STL; nervous system cytosolic sulfotransferase; Nervous system sulfotransferase; NST; rBR-STL; ST4A1; Sulfotransferase 4A1; sulfotransferase family 4A, member 1; sulfotransferase-related protein

Gene Aliases: 2400007A17Rik; AI853543; BR-STL-1; BRSTL1; DJ388M5.3; hBR-STL-1; NST; ST4A1; SULT4A1; SULTX3

UniProt ID: (Human) Q9BR01, (Mouse) P63046, (Rat) P63047

Entrez Gene ID: (Human) 25830, (Mouse) 29859, (Rat) 58953

Molecular Function: transferase metabolite interconversion enzyme