Immunogen sequence: MDAYEVSNTE FEKFVNSTGY LTEAEKFGDS FVFEGMLSEQ VKTNIQQAVA AAPWWLPVKG ANWRHPEGPD STILHR
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 91%.
This gene encodes an enzyme that catalyzes the hydrolysis of sulfate esters by oxidizing a cysteine residue in the substrate sulfatase to an active site 3-oxoalanine residue, which is also known as C-alpha-formylglycine. Mutations in this gene cause multiple sulfatase deficiency, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants.
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Protein Aliases: AAPA3037; C-alpha-formylglycine-generating enzyme; C-alpha-formylglycine-generating enzyme 1; FGE; FGly-generating enzyme; Formylglycine-generating enzyme; MGC131853; MGC150436; OTTHUMP00000115300; sulfatase modifying factor 1; Sulfatase-modifying factor 1; SUMF1
Gene Aliases: AA543204; AAPA3037; AI463102; AI851573; FGE; PSEC0152; SUMF1; UNQ3037; UNQ3037/PRO9852