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Bethyl Laboratories
SUPT6H Polyclonal Antibody
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Product Details
IHC-00211
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 425 and 475 of Human Suppressor of Ty 6 Homolog.
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Rat, Chicken, Turkey, Bovine, Dog, Horse, Rabbit, Guinea pig_10141, Pig, Panda, Orangutan, Monkey, Gorilla and Chimpanzee
Target Information
Transcription elongation factor which binds histone H3 and plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone chaperone suppressor of Ty6; hSPT6; KIAA0162; MGC87943; similar to Caenorhabditis elegans emb-5 protein; suppressor of Ty 6 homolog; Tat-cotransactivator 2 protein; Tat-CT2 protein; Transcription elongation factor SPT6
Gene Aliases: 5131400N11Rik; AI132449; emb-5; KIAA0162; mKIAA0162; SPT6; SPT6H; Supt6; SUPT6H
UniProt ID: (Human) Q7KZ85, (Mouse) Q62383
Entrez Gene ID: (Human) 6830, (Mouse) 20926
blastocyst formation
nucleobase-containing compound metabolic process
transcription elongation from RNA polymerase II promoter
mRNA processing
RNA splicing
positive regulation of transcription elongation from RNA polymerase II promoter
nucleosome organization
regulation of isotype switching
mRNA transport
regulation of muscle cell differentiation
transcription elongation-coupled chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transport
regulation of mRNA export from nucleus
regulation of DNA-templated transcription, elongation
regulation of mRNA processing
negative regulation of histone H3-K27 methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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