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Proteintech
SUV39H2 Polyclonal Antibody
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Product Details
11338-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SUV39H2 Fusion Protein Ag1882 (110-410 aa encoded by BC007754)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VKKGKAITP KDNNKTLKPA IAEYIVKKAK QRIALQRWQD ELNRRKNHKG MIFVENTVDL EGPPSDFYYI NEYKPAPGIS LVNEATFGCS CTDCFFQKCC PAEAGVLLAY NKNQQIKIPP GTPIYECNSR CQCGPDCPNR IVQKGTQYSL CIFRTSNGRG WGVKTLVKIK RMSFVMEYVG EVITSEEAER RGQFYDNKGI TYLFDLDYES DEFTVDAARY GNVSHFVNHS CDPNLQVFNV FIDNLDTRLP RIALFSTRTI NAGEELTFDY QMKGSGDISS DSIDHSPAKK RVRTVCKCGA VTCRGYLN (110-410 aa encoded by BC007754)
Target Information
The murine gene Suv39h2 encodes an H3 histone methyltransferase (HMTase) 59% identical in sequence to mouse Suv39h1. During embryogenesis, both proteins overlap in tissue expression, yet Suv39h2 transcripts are restricted to the testes in adult animals. Immunolocalization of the Suv39h2 protein during spermatogenesis indicates enrichment at the heterochromatin from the leptotene to the round spermatid stage. Moreover, Suv39h2 specifically accumulates with chromatin of the sex chromosomes, which undergo transcriptional silencing during the first meiotic prophase. Suv39h2 HMTase may also organize meiotic heterochromatin with the potential for epigenetic imprint to the male germline.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FLJ23414; H3 K9 HMTase 2; H3-K9-HMTase 2; Histone H3-K9 methyltransferase 2; histone methyltransferase SUV39H2; Histone-lysine N-methyltransferase SUV39H2; KMT1; Lysine N-methyltransferase 1B; RP11-2K17.2; Su; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2; Suv39h histone methyltransferase; SUV39H2; unnamed protein product
Gene Aliases: 4930507K23Rik; AA536750; D030054H19Rik; D2Ertd544e; KMT1B; SUV39H2
UniProt ID: (Human) Q9H5I1, (Mouse) Q9EQQ0
Entrez Gene ID: (Human) 79723, (Rat) 364785, (Mouse) 64707
transcription regulatory region sequence-specific DNA binding
protein binding
methyltransferase activity
zinc ion binding
transferase activity
histone methyltransferase activity
metal ion binding
histone methyltransferase activity (H3-K9 specific)
histone H3 methyltransferase activity
histone H3K9 trimethyltransferase activity
S-adenosyl-L-methionine binding
protein binding, bridging involved in substrate recognition for ubiquitination
RNA polymerase II regulatory region sequence-specific DNA binding
molecular_function
chromatin binding
protein methyltransferase activity
histone-lysine N-methyltransferase activity
chromatin/chromatin-binding, or -regulatory protein
histone modifying enzyme
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
chromatin remodeling
circadian rhythm
cell differentiation
methylation
epigenetic programming in the zygotic pronuclei
negative regulation of gene expression, epigenetic
negative regulation of transcription, DNA-templated
rhythmic process
cellular response to hypoxia
chromatin assembly or disassembly
male meiosis
biological_process
peptidyl-lysine methylation
histone lysine methylation
histone H3-K9 dimethylation
histone H3-K9 trimethylation
negative regulation of circadian rhythm
histone H3-K9 methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
cell cycle
chromatin modification
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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