Proteintech

SUZ12 Polyclonal Antibody

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SUZ12 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human breast cancer slide using 20366-1-AP ( SUZ12 Antibody) at dilution of 1:400.

SUZ12 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 20366-1-AP (SUZ12 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

SUZ12 Antibody in Immunoprecipitation (IP) — IP result of anti-SUZ12 (IP:20366-1-AP, 4 ug; Detection:20366-1-AP 1:500) with HeLa cells lysate 3200 ug.

Product Details

20366-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:200-1:800	-
Immunoprecipitation (IP)	0.5-4.0 µg	-
Immunohistochemistry (IHC)	-	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	Peptide
Conjugate	Unconjugated
Form	Liquid
Concentration	0.26 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Target Information

SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

TRPS1 Suppresses Breast Cancer Epithelial-mesenchymal Transition Program as a Negative Regulator of SUZ12.

Translational oncology

Hu J,Su P,Jiao M,Bai X,Qi M,Liu H,Wu Z,Sun J,Zhou G,Han B

Sun Apr 01 00:00:00 EDT 2018

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.

The EMBO journal

Wang X,Cao W,Zhang J,Yan M,Xu Q,Wu X,Wan L,Zhang Z,Zhang C,Qin X,Xiao M,Ye D,Liu Y,Han Z,Wang S,Mao L,Wei W,Chen W

Tue May 02 00:00:00 EDT 2017

Polycomb repressive complex 2 facilitates the nuclear export of the influenza viral genome through the interaction with M1.

Scientific reports

Asaka MN,Kawaguchi A,Sakai Y,Mori K,Nagata K

Tue Sep 20 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12 polycomb repressive complex 2 subunit

Gene Aliases: CHET9; JJAZ1; KIAA0160; SUZ12

UniProt ID: (Human) Q15022

Entrez Gene ID: (Human) 23512, (Rat) 688041

Molecular Function: chromatin/chromatin-binding, or -regulatory protein