This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
FIGURE: 1 / 5
Immunogen sequence: CHSRFIFNYV YHPKGARIDV SINECYDGSY AGNPQDIHRQ PGFAFSRNGP VKRTPITHIL VCRPKRTKAS MSEFLESEDG EVEQQRTYSS GHNRLYFHSD TCLPLRPQEM EVDSEDEKDP EWLREKTITQ IEEFSDVNEG EKEVMKLWNL HVMKHGFIAD NQMNHACMLF VENYGQKIIK KNLCRNFMLH LVSMHDFNLI SIMSIDKAVT KLREMQQKLE KGESASPANE EITEEQNGTA NGFSEINSKE KALETDSVSG VSKQSKKQKL; Positive Samples: HeLa, BT-474, MCF-7, 293T; Cellular Location: Nucleus
SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
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Protein Aliases: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12 polycomb repressive complex 2 subunit
Gene Aliases: 2610028O16Rik; AI195385; AU016842; AW536442; CHET9; D11Ertd530e; JJAZ1; KIAA0160; mKIAA0160; SUZ12
Molecular Function: chromatin/chromatin-binding, or -regulatory protein