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Product Details
PA5-96806
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 470-739 of human SUZ12 (NP_0561702)
Conjugate
Form
Liquid
Concentration
1.29 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808608
Product Specific Information
Immunogen sequence: CHSRFIFNYV YHPKGARIDV SINECYDGSY AGNPQDIHRQ PGFAFSRNGP VKRTPITHIL VCRPKRTKAS MSEFLESEDG EVEQQRTYSS GHNRLYFHSD TCLPLRPQEM EVDSEDEKDP EWLREKTITQ IEEFSDVNEG EKEVMKLWNL HVMKHGFIAD NQMNHACMLF VENYGQKIIK KNLCRNFMLH LVSMHDFNLI SIMSIDKAVT KLREMQQKLE KGESASPANE EITEEQNGTA NGFSEINSKE KALETDSVSG VSKQSKKQKL; Positive Samples: HeLa, BT-474, MCF-7, 293T; Cellular Location: Nucleus
Target Information
SUZ12 (polycomb protein SUZ12) is a zinc finger gene and has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. SUZ12 is also a component of the PRC2/EED-EZH2 complex which methylates Lys-9 (H3K9me) and Lys-27 (H3K27me) of histone H3 leading to transcriptional repression of the affected target gene. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Polycomb protein SUZ12; Suppressor of zeste 12 protein homolog; SUZ12 polycomb repressive complex 2 subunit
Gene Aliases: 2610028O16Rik; AI195385; AU016842; AW536442; CHET9; D11Ertd530e; JJAZ1; KIAA0160; mKIAA0160; SUZ12
UniProt ID: (Human) Q15022, (Mouse) Q80U70
Entrez Gene ID: (Human) 23512, (Mouse) 52615, (Rat) 688041
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of cell proliferation
histone methylation
histone ubiquitination
negative regulation of cell differentiation
negative regulation of gene expression, epigenetic
regulation of transcription, DNA-templated
chromatin modification
negative regulation of chemokine production
negative regulation of tyrosine phosphorylation of Stat3 protein
negative regulation of epithelial cell proliferation
histone H3-K27 trimethylation
spinal cord development
response to retinoic acid
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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