This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR ELEDMYLKLQ EALEDERQAR QDEETVRKLQ AR
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 98%.
SWAP70 is a 585 amino acid regulatory protein belonging to the pleckstrin-like family with a PH domain essential for phosphatidylinositol 3, 4, 5-trisphosphate binding. SWAP70 acts as a link between the recognition of specific switch regions and causation of a DNA break and is involved in both nuclear events and in signaling B-cell activation. As a guanine nucleotide exchange factor (GEF) it transduces signals from tyrosine kinase receptors to RAC, independent of RAS. As a multiple functional signaling protein, and a component of SWAP enzyme complex, it mediates signaling of membrane ruffling by tyrosine kinase growth factor receptors, actin cytoskeleton and cell protrusion. It is widely expressed in most tissues, mature B-cells, including those associated with mucosa-associated tissue and bronchus-associated tissue, monocytes and macrophages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ39540; HSPC321; KIAA0640; KIAA0640 protein; SWA-70 protein; SWAP complex protein; SWAP complex protein, 70 kDa; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWAP-70 protein; SWAP70; Switch-associated protein 70
Gene Aliases: 70kDa; AV235546; HSPC321; KIAA0640; SWAP-70; SWAP70
Molecular Function: nucleic acid binding