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Proteintech
SYNCRIP Polyclonal Antibody
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Product Details
30443-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
SYNCRIP fusion protein Ag31509
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
75 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: KAQRQAAKNQ MYDDYYYYGP PHMPPPTRGR GRGGRGGYGY PPDYYGYEDY YDYYGYDYHN YRGGYEDPYY GYEDFQVGAR GRGGRGARGA APSRGRGAAP PRGRAGYSQR GGPGSARGVR GARGGAQQQR GRGQGKGVEA GPDLLQ
Target Information
Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; seems not to be essential for GAIT complex function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycine- and tyrosine-rich RNA-binding protein; GRY-RBP; Heterogeneous nuclear ribonucleoprotein Q; hnRNP; hnRNP Q; NS1-associated protein 1; RRM RNA binding protein; similar to Homo sapiens Hn RNP R; Synaptotagmin-binding, cytoplasmic RNA-interacting protein; unnamed protein product
Gene Aliases: GRY-RBP; GRYRBP; hnRNP-Q; HNRNPQ; HNRPQ; HNRPQ1; NSAP1; PP68; SYNCRIP
UniProt ID: (Human) O60506
Entrez Gene ID: (Human) 10492
mRNA splicing, via spliceosome
osteoblast differentiation
RNA processing
mRNA processing
regulation of translation
RNA splicing
mRNA modification
negative regulation of translation
CRD-mediated mRNA stabilization
cellular response to interferon-gamma
chromosomal 5-methylcytosine DNA demethylation pathway
negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
positive regulation of cytoplasmic translation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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