Immunogen sequence: MKAEYDAVKA KAQKRVDLLE QVAREHEEYQ AGVDEFQLWL KAVVEKVNGC LGRNCKLPIT QRLSTLQDIA KDFPRGEESL ETLEEQSAGV IRNTSP
Highest antigen sequence identity to the following orthologs: Mouse - 78%, Rat - 77%.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: KASH domain-containing protein 3; KASH3; Nesprin-3; Nuclear envelope spectrin repeat protein 3; spectrin repeat containing, nuclear envelope family member 3
Gene Aliases: C14orf139; C14orf49; LINC00341; Nesp3; NET53; SYNE3
UniProt ID: (Human) Q6ZMZ3
Entrez Gene ID: (Human) 161176