The antibody can not recognize isoform 2 and 3 of SYNM.
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteropolymeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteropolymeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Desmuslin; Synemin; synemin alpha; synemin beta; synemin, intermediate filament protein
Gene Aliases: DMN; KIAA0353; SYN; SYNM
UniProt ID: (Human) O15061
Entrez Gene ID: (Human) 23336