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Product Details
PA5-70844
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1.0 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
synthetic peptide directed towards the middle region of human SYT10 |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.5-1.0 mg/mL |
Purification |
Affinity chromatography |
Storage buffer |
PBS with 2% sucrose |
Contains |
0.09% sodium azide |
Storage conditions |
-20° C, Avoid Freeze/Thaw Cycles |
RRID |
AB_2689779 |
Product Specific Information
This target displays homology in the following species: Cow: 79%; Dog: 86%; Guinea Pig: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Rabbit: 86%; Rat: 86%
Target Information
SYT10 is a Ca2+ sensor specifically required for the Ca2+-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. SYT10 is not involved in Ca2+-dependent synaptic vesicle exocytosis. It acts through Ca2+ and phospholipid binding to the C2 domain: Ca2+ induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DKFZp781D2042; P65; SVP65; Synaptotagmin X; Synaptotagmin-10; SYT; SYT-10; SytX
Gene Aliases: SYT10
UniProt ID: (Human) Q6XYQ8
Entrez Gene ID: (Human) 341359
Molecular Function:
membrane trafficking regulatory protein
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