Immunogen sequence: GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSM
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 90%.
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.
Protein Aliases: Exophilin-2; Granuphilin; granuphilin-a; Synaptotagmin-like protein 4
Gene Aliases: SLP4; SYTL4
UniProt ID: (Human) Q96C24
Entrez Gene ID: (Human) 94121
Molecular Function: myelin protein