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NeoBiotechnologies
Secretory Component/ECM1 Recombinant Rabbit Monoclonal Antibody (ECM1, 2889R)
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Product Details
1893-RBM3-P1
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
ECM1, 2889R
Immunogen
Recombinant human full-length ECM1 protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
ECM1, also referred to as extracellular matrix protein 1, is a protein that plays a significant role in regulating extracellular matrix organization and cell adhesion. It is expressed in various tissues, including the skin, lung, and liver, and is involved in the development and progression of several diseases, including cancer and dermatological disorders. The protein interacts with several extracellular matrix proteins, such as collagen and fibronectin, and is involved in the regulation of cell proliferation, migration, and invasion. ECM1 is also involved in endochondral bone formation, angiogenesis, and tumor biology. It interacts with various extracellular and structural proteins, contributing to the maintenance of skin integrity and homeostasis. Mutations in this gene are associated with lipoid proteinosis disorder (also known as hyalinosis cutis et mucosae or Urbach-Wiethe disease) that is characterized by generalized thickening of skin, mucosae, and certain viscera. Different isoforms of ECM1 have been described in alternatively spliced transcript variants. Diseases associated with ECM1 include Lipoid Proteinosis Of Urbach And Wiethe and Lichen Sclerosus Et Atrophicus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Extracellular matrix protein 1; RP11-54A4.6; Secretory component p85; testicular tissue protein Li 61
Gene Aliases: ECM1; URBWD
UniProt ID: (Human) Q16610, (Rat) Q62894
Entrez Gene ID: (Human) 1893, (Rat) 116662
ossification
angiogenesis
positive regulation of endothelial cell proliferation
negative regulation of cytokine-mediated signaling pathway
platelet degranulation
regulation of type 2 immune response
regulation of transcription from RNA polymerase II promoter
inflammatory response
signal transduction
negative regulation of peptidase activity
negative regulation of bone mineralization
biomineral tissue development
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of angiogenesis
regulation of T cell migration
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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