Immunogen sequence: MATLIYVDKE NGEPGTRVVA KDGLKLGSGP SIKALDGRSQ VSTPRFGKTF DAPPALPKAT RKALGTVNRA TEKSVKTKGP LKQKQPSFSA KKMTEKTVKA KSSVPASDDA YPEIEKFFPF NPLDFESFDL PEEHQIAHLP LSGVPLMILD EERELEKLFQ LGPPSPVKMP SPPWESNLLQ SPSSILSTLD VELPPVCCDI DI; Positive Samples: SW480, Jurkat, HeLa, Mouse stomach, Mouse thymus, Mouse spleen, Rat testis; Cellular Location: Cytoplasm, Nucleus
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.
Protein Aliases: Esp1-associated protein; ESP1-associated protein 1; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; Pituitary tumor-transforming gene 1 protein; Securin; Tumor-transforming protein 1
Gene Aliases: AW555095; C87862; EAP1; HPTTG; PTTG; PTTG1; Pttg3; TUTR1