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Sema3C Polyclonal Antibody
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Product Details
BS-6692R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Sema3C, amino acids 51-150.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The SEMA3C gene encodes the protein semaphorin 3C, a member of the semaphorin family known for its roles in axonal guidance, cellular signaling, and vascular development. Semaphorin 3C is involved in guiding neurons during development by serving as a repulsive cue, helping establish proper neural network formation through interaction with neuropilin and plexin receptors. It also plays crucial roles in angiogenesis and cardiac development by influencing endothelial cell behavior and migration. In the context of cancer, SEMA3C is implicated in tumor progression, where its dysregulation can promote tumor cell invasion and metastasis by modifying the extracellular matrix and affecting cellular adhesion. Research has demonstrated that SEMA3C can alter the tumor microenvironment, making it a potential target for cancer therapies aimed at inhibiting metastasis and controlling tumor growth. Understanding SEMA3C's function in various biological processes continues, highlighting its significance in developmental biology and disease modulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Sema E; semaphorin E; Semaphorin-3C; Semaphorin-E; unnamed protein product
Gene Aliases: 1110036B02Rik; SEMA3C; SEMAE; SemE
UniProt ID: (Human) Q99985, (Mouse) Q62181
Entrez Gene ID: (Human) 10512, (Mouse) 20348, (Rat) 296787
neural crest cell migration
somitogenesis
blood vessel remodeling
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac right ventricle morphogenesis
pulmonary myocardium development
immune response
nervous system development
axon guidance
heart development
response to xenobiotic stimulus
post-embryonic development
neural tube development
cell differentiation
positive regulation of cell migration
negative chemotaxis
limb bud formation
dichotomous subdivision of terminal units involved in salivary gland branching
semaphorin-plexin signaling pathway
cardiac endothelial to mesenchymal transition
positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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