Suggested positive control: A431 whole cell extracts.
Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms.
Protein Aliases: Caspase-like protein ESPL1; extra spindle pole bodies 1, separase; extra spindle pole bodies homolog 1; extra spindle poles like 1; Extra spindle poles-like 1 protein; FLJ46492; Separase; Separin; separin, cysteine protease
Gene Aliases: ESP1; ESPL1; KIAA0165; SEPA
UniProt ID: (Human) Q14674
Entrez Gene ID: (Human) 9700
Molecular Function: nucleic acid binding