Immunogen sequence: MEPPASKVPE VPTAPATDAA PKRVEIQMPK PAEAPTAPSP AQTLENSEPA PVSQLQSRLE PKPQPPVAEA TPRSQEATEA APSCVGDMAD TPRDAGLKQA PASRNEKAPV; Positive Samples: Jurkat, HeLa, 293T, U-87MG; Cellular Location: Cytoplasm, cytoskeleton
The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucinezipper motifs, which allow homodimerization as well as heterodimerization with a variety of other bZip transcription factors. Large Mafs also contain an acidic transactivation domain absent in the small Maf proteins. Although they do not possess inherent transactivation activity, small Maf proteins can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, small Mafs can act also as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can replace active dimers. Human MafF was isolated in a yeast one-hybrid system from a human myometrium cDNA library. Human MAFF encodes a 164 amino acids proten. Like other small MAFF proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Interestingly, these three proteins regulate the stress response via different mechanisms.
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Protein Aliases: E-septin; Eighth septin; Eseptin; MLL septin-like fusion; MLL septin-like fusion protein; MLL septin-like fusion protein MSF-A; Ov/Br septin; Ovarian/Breast septin; Septin D1; Septin-9; Septin-like protein; SL3-3 integration site 1 protein; SLP
Gene Aliases: AF17q25; Eseptin; KIAA0991; MSF; MSF1; NAPB; PNUTL4; SEPT9; SeptD1; SEPTIN9; SINT1; Slpa