Product References
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 EDT 2020
Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling.
Cell death discovery
Ebnoether E,Ramseier A,Cortada M,Bodmer D,Levano-Huaman S
Tue Sep 29 00:00:00 EDT 2020
Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling.
Journal of biophotonics
Xia J,Zeng W,Xia Y,Wang B,Xu D,Liu D,Kong MG,Dong Y
Tue Jan 01 00:00:00 EST 2019
Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax.
Marine drugs
Florean C,Kim KR,Schnekenburger M,Kim HJ,Moriou C,Debitus C,Dicato M,Al-Mourabit A,Han BW,Diederich M
Wed Dec 19 00:00:00 EST 2018
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
Free radical biology & medicine
Shin D,Kim EH,Lee J,Roh JL
Sat Dec 01 00:00:00 EST 2018
Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions.
Journal of cellular biochemistry
Sundararajan S,Jayachandran I,Balasubramanyam M,Mohan V,Venkatesan B,Manickam N
Sun Nov 18 00:00:00 EST 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 EDT 2018
Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma.
Cancer medicine
Dai J,Huang Q,Niu K,Wang B,Li Y,Dai C,Chen Z,Tao K,Dai J
Thu Nov 01 00:00:00 EDT 2018
The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells.
DNA repair
Zheng Y,Lei Q,Jongejan A,Mulder CL,van Daalen SKM,Mastenbroek S,Hwang G,Jordan PW,Repping S,Hamer G
Mon Oct 01 00:00:00 EDT 2018
Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins.
Biochimica et biophysica acta. Molecular basis of disease
Wang T,Niu Y,Liu S,Yuan H,Liu X,Fu L
Mon Oct 01 00:00:00 EDT 2018
RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells.
Molecular and cellular biochemistry
Kumar A,Shaha C
Sat Sep 01 00:00:00 EDT 2018
Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2.
The American journal of Chinese medicine
Jung JY,Park SM,Ko HL,Lee JR,Park CA,Byun SH,Ku SK,Cho IJ,Kim SC
Fri Aug 03 00:00:00 EDT 2018
The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle.
European journal of applied physiology
Zeng N,D'Souza RF,Sorrenson B,Merry TL,Barnett MPG,Mitchell CJ,Cameron-Smith D
Fri Jun 01 00:00:00 EDT 2018
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway.
Journal of molecular and cellular cardiology
Quan N,Wang L,Chen X,Luckett C,Cates C,Rousselle T,Zheng Y,Li J
Thu Feb 01 00:00:00 EST 2018
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation.
Scientific reports
Kumar A,Shaha C
Fri Jan 12 00:00:00 EST 2018
Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Kim JK,Lee JE,Jung EH,Jung JY,Jung DH,Ku SK,Cho IJ,Kim SC
Mon Jan 01 00:00:00 EST 2018
Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle.
Physiological reports
Zeng N,D'Souza RF,Figueiredo VC,Markworth JF,Roberts LA,Peake JM,Mitchell CJ,Cameron-Smith D
Fri Dec 01 00:00:00 EST 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 EDT 2017
Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea.
Neuroscience
Zhang C,Sun W,Li J,Xiong B,Frye MD,Ding D,Salvi R,Kim MJ,Someya S,Hu BH
Wed Oct 11 00:00:00 EDT 2017
Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2α-ATF4 pathway.
Free radical biology & medicine
Kim HJ,Joe Y,Kim SK,Park SU,Park J,Chen Y,Kim J,Ryu J,Cho GJ,Surh YJ,Ryter SW,Kim UH,Chung HT
Fri Sep 01 00:00:00 EDT 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 EDT 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 EDT 2017
A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells.
Cell reports
Byun JK,Choi YK,Kim JH,Jeong JY,Jeon HJ,Kim MK,Hwang I,Lee SY,Lee YM,Lee IK,Park KG
Tue Jul 18 00:00:00 EDT 2017
Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Biochimica et biophysica acta. Molecular cell research
Jegal KH,Park SM,Cho SS,Byun SH,Ku SK,Kim SC,Ki SH,Cho IJ
Sat Jul 01 00:00:00 EDT 2017
The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1.
PloS one
Mlitz V,Gendronneau G,Berlin I,Buchberger M,Eckhart L,Tschachler E
Mon Jun 26 00:00:00 EDT 2017
Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome.
Experimental and therapeutic medicine
Xing Y,Liu YX,Liu X,Wang SL,Li P,Lin XH,Sui CL,Xu C,Qi B,Tong Q
Thu Jun 01 00:00:00 EDT 2017
Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function.
Matrix biology : journal of the International Society for Matrix Biology
Tomasovic A,Kurrle N,Wempe F,De-Zolt S,Scheibe S,Koli K,Serchinger M,Schnütgen F,Sürün D,Sterner-Kock A,Weissmann N,von Melchner H
Mon May 01 00:00:00 EDT 2017
Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Experimental cell research
Li H,Liu S,Yuan H,Niu Y,Fu L
Mon May 01 00:00:00 EDT 2017
Sestrin2 protects against acetaminophen-induced liver injury.
Chemico-biological interactions
Kim SJ,Kim KM,Yang JH,Cho SS,Kim JY,Park SJ,Lee SK,Ku SK,Cho IJ,Ki SH
Mon May 01 00:00:00 EDT 2017
SZT2 dictates GATOR control of mTORC1 signalling.
Nature
Peng M,Yin N,Li MO
Thu Mar 16 00:00:00 EDT 2017
5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells.
Archives of pharmacal research
Seo K,Ki SH,Park EY,Shin SM
Wed Feb 01 00:00:00 EST 2017
Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production.
Biological & pharmaceutical bulletin
Seo K,Seo S,Ki SH,Shin SM
Fri Jan 27 00:00:00 EST 2017
Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes.
Photochemistry and photobiology
Zhao B,Shah P,Qiang L,He TC,Budanov A,He YY
Sun Jan 01 00:00:00 EST 2017
Sestrin2 inhibits hypoxia-inducible factor-1α accumulation via AMPK-mediated prolyl hydroxylase regulation.
Free radical biology & medicine
Seo K,Seo S,Ki SH,Shin SM
Thu Dec 01 00:00:00 EST 2016
p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death.
Free radical research
Park JS,Oh SY,Lee DH,Lee YS,Sung SH,Ji HW,Lee MJ,Lee YH,Rhee SG,Bae SH
Thu Dec 01 00:00:00 EST 2016
Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.
Cell cycle (Georgetown, Tex.)
Ding B,Parmigiani A,Yang C,Budanov AV
Thu Aug 18 00:00:00 EDT 2016
SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages.
Autophagy
Kim MJ,Bae SH,Ryu JC,Kwon Y,Oh JH,Kwon J,Moon JS,Kim K,Miyawaki A,Lee MG,Shin J,Kim YS,Kim CH,Ryter SW,Choi AM,Rhee SG,Ryu JH,Yoon JH
Tue Aug 02 00:00:00 EDT 2016
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation.
Cellular signalling
Kimball SR,Gordon BS,Moyer JE,Dennis MD,Jefferson LS
Mon Aug 01 00:00:00 EDT 2016
Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons.
Molecular neurobiology
Wu CL,Chen SD,Yin JH,Hwang CS,Yang DI
Mon Aug 01 00:00:00 EDT 2016
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats.
Scientific reports
Li L,Xiao L,Hou Y,He Q,Zhu J,Li Y,Wu J,Zhao J,Yu S,Zhao Y
Mon Jul 25 00:00:00 EDT 2016
Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress.
Toxicological sciences : an official journal of the Society of Toxicology
Sun W,Quan N,Wang L,Yang H,Chu D,Liu Q,Zhao X,Leng J,Li J
Sun May 01 00:00:00 EDT 2016
Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress.
Apoptosis : an international journal on programmed cell death
Jegal KH,Ko HL,Park SM,Byun SH,Kang KW,Cho IJ,Kim SC
Sun May 01 00:00:00 EDT 2016
Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency.
Cell reports
Reddy K,Cusack CL,Nnah IC,Khayati K,Saqcena C,Huynh TB,Noggle SA,Ballabio A,Dobrowolski R
Tue Mar 08 00:00:00 EST 2016
Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death.
Scientific reports
Ding B,Parmigiani A,Divakaruni AS,Archer K,Murphy AN,Budanov AV
Wed Mar 02 00:00:00 EST 2016
Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis.
eLife
Ro SH,Xue X,Ramakrishnan SK,Cho CS,Namkoong S,Jang I,Semple IA,Ho A,Park HW,Shah YM,Lee JH
Thu Feb 25 00:00:00 EST 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 EST 2016
p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb.
Molecular cancer research : MCR
Agarwal S,Bell CM,Taylor SM,Moran RG
Fri Jan 01 00:00:00 EST 2016
Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Cellular signalling
Yamani L,Li B,Larose L
Tue Dec 01 00:00:00 EST 2015
Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.
Nature communications
Kim H,An S,Ro SH,Teixeira F,Park GJ,Kim C,Cho CS,Kim JS,Jakob U,Lee JH,Cho US
Fri Nov 27 00:00:00 EST 2015
GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2.
Genes & development
Ye J,Palm W,Peng M,King B,Lindsten T,Li MO,Koumenis C,Thompson CB
Sun Nov 15 00:00:00 EST 2015
Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet.
The Journal of nutrition
Kimball SR,Ravi S,Gordon BS,Dennis MD,Jefferson LS
Sun Nov 01 00:00:00 EDT 2015
Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity.
Cellular signalling
Seo K,Ki SH,Shin SM
Wed Jul 01 00:00:00 EDT 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 EDT 2015
Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions.
The Journal of biological chemistry
Tomasovic A,Kurrle N,Sürün D,Heidler J,Husnjak K,Poser I,Schnütgen F,Scheibe S,Seimetz M,Jaksch P,Hyman A,Weissmann N,von Melchner H
Fri Apr 10 00:00:00 EDT 2015
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Toxicological sciences : an official journal of the Society of Toxicology
Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH
Wed Apr 01 00:00:00 EDT 2015
Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages.
Toxicological sciences : an official journal of the Society of Toxicology
Kim MG,Yang JH,Kim KM,Jang CH,Jung JY,Cho IJ,Shin SM,Ki SH
Wed Apr 01 00:00:00 EDT 2015
Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling.
Diabetes
Tao R,Xiong X,Liangpunsakul S,Dong XC
Wed Apr 01 00:00:00 EDT 2015
Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway.
International journal of endocrinology
Chai D,Wang G,Zhou Z,Yang H,Yu Z
Fri Mar 20 00:00:00 EDT 2015
Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Morrison A,Chen L,Wang J,Zhang M,Yang H,Ma Y,Budanov A,Lee JH,Karin M,Li J
Sun Feb 01 00:00:00 EST 2015
Role of sestrin2 in the regulation of proinflammatory signaling in macrophages.
Free radical biology & medicine
Yang JH,Kim KM,Kim MG,Seo KH,Han JY,Ka SO,Park BH,Shin SM,Ku SK,Cho IJ,Ki SH
Thu Jan 01 00:00:00 EST 2015
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 EST 2014
Sestrin2 protein positively regulates AKT enzyme signaling and survival in human squamous cell carcinoma and melanoma cells.
The Journal of biological chemistry
Zhao B,Shah P,Budanov AV,Qiang L,Ming M,Aplin A,Sims DM,He YY
Fri Dec 26 00:00:00 EST 2014
Autophagy and senescence, stress responses induced by the DNA-damaging mycotoxin alternariol.
Toxicology
Solhaug A,Torgersen ML,Holme JA,Lagadic-Gossmann D,Eriksen GS
Thu Dec 04 00:00:00 EST 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 EST 2014
Sestrins inhibit mTORC1 kinase activation through the GATOR complex.
Cell reports
Parmigiani A,Nourbakhsh A,Ding B,Wang W,Kim YC,Akopiants K,Guan KL,Karin M,Budanov AV
Thu Nov 20 00:00:00 EST 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 EDT 2014
Sestrin2 decreases renal oxidative stress, lowers blood pressure, and mediates dopamine D2 receptor-induced inhibition of reactive oxygen species production.
Hypertension (Dallas, Tex. : 1979)
Yang Y,Cuevas S,Yang S,Villar VA,Escano C,Asico L,Yu P,Jiang X,Weinman EJ,Armando I,Jose PA
Wed Oct 01 00:00:00 EDT 2014
Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.
Cell
Peng M,Yin N,Li MO
Thu Sep 25 00:00:00 EDT 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 EDT 2014
Expression of a novel stress-inducible protein, sestrin 2, in rat glomerular parietal epithelial cells.
American journal of physiology. Renal physiology
Hamatani H,Hiromura K,Sakairi T,Takahashi S,Watanabe M,Maeshima A,Ohse T,Pippin JW,Shankland SJ,Nojima Y
Mon Sep 15 00:00:00 EDT 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 EDT 2014
Sestrin2 promotes Unc-51-like kinase 1 mediated phosphorylation of p62/sequestosome-1.
The FEBS journal
Ro SH,Semple IA,Park H,Park H,Park HW,Kim M,Kim JS,Lee JH
Mon Sep 01 00:00:00 EDT 2014
Regulatory effects of sestrin 3 (SESN3) in BCR-ABL expressing cells.
PloS one
Vakana E,Arslan AD,Szilard A,Altman JK,Platanias LC
Mon Jul 07 00:00:00 EDT 2014
Hepatoprotective role of Sestrin2 against chronic ER stress.
Nature communications
Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH
Fri Jun 20 00:00:00 EDT 2014
Hepatoprotective role of Sestrin2 against chronic ER stress.
Nature communications
Park HW,Park H,Ro SH,Jang I,Semple IA,Kim DN,Kim M,Nam M,Zhang D,Yin L,Lee JH
Fri Jun 20 00:00:00 EDT 2014
Sestrin2 inhibits uncoupling protein 1 expression through suppressing reactive oxygen species.
Proceedings of the National Academy of Sciences of the United States of America
Ro SH,Nam M,Jang I,Park HW,Park H,Semple IA,Kim M,Kim JS,Park H,Einat P,Damari G,Golikov M,Feinstein E,Lee JH
Tue May 27 00:00:00 EDT 2014
Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.
International journal of molecular medicine
Kim GT,Lee SH,Kim JI,Kim YM
Tue Apr 01 00:00:00 EDT 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 EST 2014
Induction of sestrin2 as an endogenous protective mechanism against amyloid beta-peptide neurotoxicity in primary cortical culture.
Experimental neurology
Chen YS,Chen SD,Wu CL,Huang SS,Yang DI
Sat Mar 01 00:00:00 EST 2014
p53/TAp63 and AKT regulate mammalian target of rapamycin complex 1 (mTORC1) signaling through two independent parallel pathways in the presence of DNA damage.
The Journal of biological chemistry
Cam M,Bid HK,Xiao L,Zambetti GP,Houghton PJ,Cam H
Fri Feb 14 00:00:00 EST 2014
Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury.
Antioxidants & redox signaling
Kallenborn-Gerhardt W,Lu R,Syhr KM,Heidler J,von Melchner H,Geisslinger G,Bangsow T,Schmidtko A
Tue Dec 10 00:00:00 EST 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 EDT 2013
The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Forsberg K,Wuttke A,Quadrato G,Chumakov PM,Wizenmann A,Di Giovanni S
Wed Sep 04 00:00:00 EDT 2013
Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells.
Journal of cancer prevention
Kim GT,Lee SH,Kim YM
Sun Sep 01 00:00:00 EDT 2013
The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.
Hepatology (Baltimore, Md.)
Buitrago-Molina LE,Marhenke S,Longerich T,Sharma AD,Boukouris AE,Geffers R,Guigas B,Manns MP,Vogel A
Sun Sep 01 00:00:00 EDT 2013
Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.
Toxicology and applied pharmacology
Jin SH,Yang JH,Shin BY,Seo K,Shin SM,Cho IJ,Ki SH
Thu Aug 15 00:00:00 EDT 2013
Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death.
Cell death and differentiation
Ben-Sahra I,Dirat B,Laurent K,Puissant A,Auberger P,Budanov A,Tanti JF,Bost F
Mon Apr 01 00:00:00 EDT 2013
Mechanisms involved in alternariol-induced cell cycle arrest.
Mutation research
Solhaug A,Vines LL,Ivanova L,Spilsberg B,Holme JA,Pestka J,Collins A,Eriksen GS
Tue Feb 26 00:00:00 EST 2013
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 EST 2013
Sestrins activate Nrf2 by promoting p62-dependent autophagic degradation of Keap1 and prevent oxidative liver damage.
Cell metabolism
Bae SH,Sung SH,Oh SY,Lim JM,Lee SK,Park YN,Lee HE,Kang D,Rhee SG
Tue Jan 08 00:00:00 EST 2013
Maintenance of metabolic homeostasis by Sestrin2 and Sestrin3.
Cell metabolism
Lee JH,Budanov AV,Talukdar S,Park EJ,Park HL,Park HW,Bandyopadhyay G,Li N,Aghajan M,Jang I,Wolfe AM,Perkins GA,Ellisman MH,Bier E,Scadeng M,Foretz M,Viollet B,Olefsky J,Karin M
Wed Sep 05 00:00:00 EDT 2012
Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125.
Biochemical pharmacology
Caporali S,Alvino E,Levati L,Esposito AI,Ciomei M,Brasca MG,Del Bufalo D,Desideri M,Bonmassar E,Pfeffer U,D'Atri S
Sat Sep 01 00:00:00 EDT 2012
Antioxidant sestrin-2 redistribution to neuronal soma in human immunodeficiency virus-associated neurocognitive disorders.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Soontornniyomkij V,Soontornniyomkij B,Moore DJ,Gouaux B,Masliah E,Tung S,Vinters HV,Grant I,Achim CL
Sat Sep 01 00:00:00 EDT 2012
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Free radical biology & medicine
Shin BY,Jin SH,Cho IJ,Ki SH
Wed Aug 15 00:00:00 EDT 2012
Nrf2-ARE pathway regulates induction of Sestrin-2 expression.
Free radical biology & medicine
Shin BY,Jin SH,Cho IJ,Ki SH
Wed Aug 15 00:00:00 EDT 2012
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 EDT 2012
Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells.
PloS one
Sanli T,Linher-Melville K,Tsakiridis T,Singh G
Fri Jun 29 00:00:00 EDT 2012
Highly reactive meso-like positions of dipyrihexaphyrin.
Chemical communications (Cambridge, England)
Setsune J,Yamato K
Fri May 11 00:00:00 EDT 2012
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine.
American journal of physiology. Endocrinology and metabolism
Lang CH,Frost RA,Bronson SK,Lynch CJ,Vary TC
Tue Jun 01 00:00:00 EDT 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 EDT 2010
Inactivation of sestrin 2 induces TGF-beta signaling and partially rescues pulmonary emphysema in a mouse model of COPD.
Disease models & mechanisms
Wempe F,De-Zolt S,Koli K,Bangsow T,Parajuli N,Dumitrascu R,Sterner-Kock A,Weissmann N,Keski-Oja J,von Melchner H
Wed May 26 00:00:00 EDT 2010
Role of sestrin2 in peroxide signaling in macrophages.
FEBS letters
Essler S,Dehne N,Brüne B
Tue Nov 03 00:00:00 EST 2009
Artemis is a negative regulator of p53 in response to oxidative stress.
Oncogene
Zhang X,Zhu Y,Geng L,Wang H,Legerski RJ
Thu Jun 04 00:00:00 EDT 2009
Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.
Journal of neurochemistry
Doonan F,Wallace DM,O'Driscoll C,Cotter TG
Wed Apr 01 00:00:00 EDT 2009
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Antioxidants & redox signaling
Woo HA,Bae SH,Park S,Rhee SG
Wed Apr 01 00:00:00 EDT 2009
Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins.
Antioxidants & redox signaling
Woo HA,Bae SH,Park S,Rhee SG
Wed Apr 01 00:00:00 EDT 2009
A novel antioxidant function for the tumor-suppressor gene p53 in the retinal ganglion cell.
Investigative ophthalmology & visual science
O'Connor JC,Wallace DM,O'Brien CJ,Cotter TG
Wed Oct 01 00:00:00 EDT 2008
Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure.
Journal of cell science
Ding B,Chi SG,Kim SH,Kang S,Cho JH,Kim DS,Cho NH
Sun Jul 01 00:00:00 EDT 2007
peroxidase
