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|Tested species reactivity||Mouse , Rat|
|Published species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the rat sigma-1 receptor, which differs from mouse and human by one conservative amino acid change and is predicted to be identical to dog, bovine, and ermine|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 2 publications below|
This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Alternative splicing of this gene results in transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Sigma-1 receptor expression in sensory neurons and the effect of painful peripheral nerve injury.
42-3300 was used in western blot to examine σR expression in dorsal root ganglion at baseline and following spinal nerve ligation in rats.
|Bangaru ML,Weihrauch D,Tang QB,Zoga V,Hogan Q,Wu HE||Molecular pain (9:null)||2013|
Sigma-1 receptors amplify dopamine D1 receptor signaling at presynaptic sites in the prelimbic cortex.
||Fu Y,Zhao Y,Luan W,Dong LY,Dong Y,Lai B,Zhu Y,Zheng P||Biochimica et biophysica acta (1803:1396)||2010|
opioid receptor, sigma 1, sigma 1 receptor variant SR-1D, sigma 1-type opioid receptor, sigma non-opioid intracellular receptor 1, sigma1-receptor, sigma1R, ALS16, OPRS1, SR-BP1, SRBP, SIG-1R, SR-BP, SR31747 binding protein 1, aging-associated gene 8 protein, hSigmaR1