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Sin3b Polyclonal Antibody
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Product Details
BS-4215R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Sin3b, amino acids 261-360.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Histone deacetylase complex subunit Sin3b; Paired amphipathic helix protein Sin3b; SIN3 homolog B, transcription regulator; SIN3 homolog B, transcriptional regulator; SIN3 transcription regulator homolog B; Transcriptional corepressor Sin3b; transcriptional regulator; transcriptional regulator, SIN3 yeast homolog B; transcriptional regulator, SIN3B; unnamed protein product
Gene Aliases: 2810430C10Rik; KIAA0700; SIN3B
UniProt ID: (Human) O75182, (Mouse) Q62141
Entrez Gene ID: (Human) 23309, (Rat) 683381, (Mouse) 20467
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of cell migration
negative regulation of transcription, DNA-templated
skeletal muscle tissue development
biological_process
histone deacetylation
cardiac muscle tissue development
transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of cell cycle
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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