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Product Details
BS-0444R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human SLC22A17, amino acids 475-538.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 24p3 receptor; 24p3R; brain-specific organic ion transporter; Brain-type organic cation transporter; Lipocalin-2 receptor; Neutrophil gelatinase-associated lipocalin receptor; NGAL receptor; NgalR; organic cation transporter BOCT; potent brain type organic ion transporter; solute carrier family 22 (organic cation transporter), member 17; Solute carrier family 22 member 17; solute carrier family 22, member 17
Gene Aliases: 1700094C23Rik; 24p3R; AU041908; AW555662; BOCT; BOIT; hBOIT; mBOCT; NGALR; NGALR2; NGALR3; rBOCT; SLC22A17
UniProt ID: (Human) Q8WUG5, (Mouse) Q9D9E0, (Rat) Q9P290
Entrez Gene ID: (Human) 51310, (Mouse) 59049, (Rat) 305886
Performance Guarantee
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