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Invitrogen
Slc30A8 Polyclonal Antibody
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FIGURE: 1 / 4
Slc30A8 Antibody (PA5-103252) in ICC/IF
Immunofluorescent analysis of Slc30A8 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Slc30A8 polyclonal antibody (Product # PA5-103252) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-103252
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SLC30A8(Accession Q8IWU4), corresponding to amino acid residues I179-I229.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SLC30A8.
Target Information
Slc30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of Slc30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes, but no genetic association has been found with Type 1 diabetes. Slc30A8 expression in b-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1 beta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Proton-coupled zinc antiporter SLC30A8; solute carrier family 30 (zinc transporter), member 8; Solute carrier family 30 member 8; unnamed protein product; Zinc transporter 8; zinc transporter ZnT-8; ZnT-8
Gene Aliases: SLC30A8; ZnT-8; ZNT8
UniProt ID: (Human) Q8IWU4
Entrez Gene ID: (Human) 169026
ion transport
cation transport
zinc II ion transport
cellular zinc ion homeostasis
response to glucose
response to zinc ion
insulin processing
insulin secretion
positive regulation of insulin secretion
response to interferon-gamma
glucose homeostasis
transmembrane transport
regulation of vesicle-mediated transport
zinc ion import into organelle
response to interleukin-1
zinc II ion transmembrane transport
zinc II ion transmembrane import
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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