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Invitrogen
SnoN Polyclonal Antibody
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Product Details
PA5-20306
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide from near the amino terminus of human SnoN.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is A431 cell lysate.
PA5-20306 can be used with blocking peptide PEP-0400.
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Like Ski, SnoN functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. SnoN is located primarily in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: SKI-like oncogene; Ski-like protein; Ski-related oncogene; ski-related oncogene snoN; Ski-related protein; ski/sno related
Gene Aliases: SKIL; Skir; SNO; SnoA; SnoI; SnoN
UniProt ID: (Human) A6NGT1, (Mouse) Q60665
Entrez Gene ID: (Human) 6498, (Rat) 114208, (Mouse) 20482
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
protein binding
SMAD binding
molecular_function
DNA binding
transcription corepressor activity
protein domain specific binding
protein complex binding
negative regulation of transcription from RNA polymerase II promoter
blastocyst formation
lymphocyte homeostasis
cell cycle arrest
transforming growth factor beta receptor signaling pathway
spermatogenesis
negative regulation of transforming growth factor beta receptor signaling pathway
response to cytokine
regulation of apoptotic process
negative regulation of cell differentiation
positive regulation of axonogenesis
lens fiber cell differentiation
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
skeletal muscle tissue development
response to antibiotic
protein homotrimerization
protein heterotrimerization
response to growth factor
transcription from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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