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Invitrogen

Sodium Channel Pan Polyclonal Antibody

View all (8) Sodium Channel Pan antibodies
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-104156

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SCN11A, corresponding to a region within the internal amino acids.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

RRID

AB_2853484

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-Feb; brain III voltage-gated sodium channel; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CTC-264K15.6; HBSC II; hH1; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; Neuroendocrine sodium channel; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PN1; PN3; PN5; Sensory neuron sodium channel 2; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain type 2 alpha subunit; sodium channel voltage gated type 1 alpha subunit; sodium channel, voltage gated, type I alpha subunit; sodium channel, voltage gated, type II alpha subunit; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type IV alpha subunit; sodium channel, voltage gated, type IX alpha subunit; sodium channel, voltage gated, type V alpha subunit; sodium channel, voltage gated, type VIII alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage gated, type X alpha subunit; sodium channel, voltage gated, type XI alpha subunit; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; SP-19; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein

Gene Aliases: BFIC3; BFIS3; BFNIS; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; EIEE11; EIEE13; EIEE6; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FHM3; GEFSP2; GEFSP7; HB1; HB2; HBA; HBBD; HBSCI; HBSCII; HH1; HOKPP2; hPN3; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; LQT3; MED; Na(v)1.2; Na(V)1.4; NAC1; NAC1A; NAC2; NAC3; NaCh6; NaN; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.6; Nav1.7; Nav1.8; NAV1.9; NE-NA; NENA; PFHB1; PN1; PN3; PN4; PN5; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; SFNP; SkM1; SMEI; SNS; SNS-2; SNS2; SSS1; VF1

UniProt ID: (Human) Q9Y5Y9, (Human) Q9UI33, (Human) P35498, (Human) Q99250, (Human) Q9NY46, (Human) P35499, (Human) Q14524, (Human) Q9UQD0, (Human) Q15858

Entrez Gene ID: (Human) 6336, (Human) 11280, (Human) 6323, (Human) 6326, (Human) 6328, (Human) 6329, (Human) 6331, (Human) 6334, (Human) 6335

Molecular Function: voltage-gated ion channel

Function(s)
regulation of heart rate sensory perception neuronal action potential sensory perception of pain regulation of ion transmembrane transport sodium ion transmembrane transport odontogenesis of dentin-containing tooth regulation of cardiac muscle contraction regulation of postsynaptic membrane potential regulation of atrial cardiac muscle cell membrane depolarization membrane depolarization during action potential AV node cell action potential bundle of His cell action potential sodium ion transport response to drug regulation of sensory perception of pain positive regulation of defense response to virus by host adult walking behavior neuronal action potential propagation neuromuscular process controlling posture xenophagy intrinsic apoptotic signaling pathway in response to osmotic stress myelination neuron apoptotic process nervous system development response to wounding response to pyrethroid cellular response to antibiotic potassium ion transport muscle contraction choline transport cardiac ventricle development brainstem development positive regulation of sodium ion transport response to denervation involved in regulation of muscle adaptation telencephalon development cerebellum development positive regulation of action potential positive regulation of epithelial cell proliferation membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane depolarization cardiac conduction cellular response to calcium ion cardiac muscle cell action potential involved in contraction regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential SA node cell action potential membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction regulation of sodium ion transmembrane transport peripheral nervous system development inflammatory response response to toxic substance post-embryonic development behavioral response to pain
Process(es)
voltage-gated sodium channel activity ion channel binding sodium ion binding calmodulin binding protein binding fibroblast growth factor binding enzyme binding protein kinase binding protein domain specific binding ankyrin binding ubiquitin protein ligase binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in AV node cell action potential voltage-gated sodium channel activity involved in bundle of His cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential voltage-gated sodium channel activity involved in SA node cell action potential scaffold protein binding ATP binding
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