Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
0.5-2 µg/mL | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:200 | - |
Immunocytochemistry (ICC/IF) |
2-5 µg/mL | - |
Product Specifications | |
---|---|
Species Reactivity |
Bovine, Dog, Horse, Human, Mouse, Non-human primate, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide (60 QSGIAGGYKPFNLET 74) of Sorcin protein. |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
1.0 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2540670 |
Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells; CP-22; CP22; H_RG167B05.1; Sorcin; V19
Gene Aliases: 2210417O06Rik; 2900070H08Rik; CP-22; CP22; SCN; Sor; SRI; V19
UniProt ID: (Human) P30626, (Mouse) Q6P069
Entrez Gene ID: (Human) 6717, (Bovine) 508319, (Horse) 100059619, (Dog) 475220, (Mouse) 109552, (Rat) 683667
Molecular Function:
actin or actin-binding cytoskeletal protein
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