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Product Details
PA5-23143
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Partial synthetic peptide made to an internal region of the human SRI protein (between amino acids 45-90) [UniProt P30626]
Conjugate
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2540670
Target Information
Sorcin is a 198 amino acid, soluble, resistance-related, calcium-binding cytosolic protein belonging to the penta-EF hand (PEF) family of calcium binding proteins and contains 4 EF-hand calcium-binding motifs. Human Sorcin is known to share 95% sequence identity with hamster Sorcin. It is known to associate with the sarcolemmal proteins Annexin VII, cardiac ryanodine receptors and L-type Ca2+ channels and thus influence the intracellular Ca (2+)-homeostasis. It is also important in the regulation of intracellular Ca2+ cycling and Ca2+ influx pathways in the heart and skeletal muscle during excitation-contraction. It is overproduced in many multi-drug resistance (MDR) cells and regulates cell apoptosis pathways, thus acting as a new MDR marker for prognosis of acute myeloid leukemia (AML) and a good target for anti-MDR drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 22 kDa protein; calcium binding protein amplified in mutlidrug-resistant cells; CP-22; CP22; H_RG167B05.1; Sorcin; V19
Gene Aliases: 2210417O06Rik; 2900070H08Rik; CP-22; CP22; SCN; Sor; SRI; V19
UniProt ID: (Human) P30626, (Mouse) Q6P069
Entrez Gene ID: (Human) 6717, (Bovine) 508319, (Horse) 100059619, (Dog) 475220, (Mouse) 109552, (Rat) 683667
Molecular Function:
actin or actin-binding cytoskeletal protein
action potential
proteolysis
transport
calcium ion transport
intracellular sequestering of iron ion
regulation of striated muscle contraction
signal transduction
heart development
muscle organ development
regulation of heart contraction
negative regulation of heart rate
regulation of cell communication by electrical coupling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of insulin secretion involved in cellular response to glucose stimulus
cytoplasmic sequestering of transcription factor
positive regulation of release of sequestered calcium ion into cytosol
regulation of calcium ion transport
negative regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell contraction
regulation of relaxation of muscle
regulation of high voltage-gated calcium channel activity
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of transcription regulatory region DNA binding
Performance Guarantee
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