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Invitrogen
Spectrin alpha-1 Polyclonal Antibody
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FIGURE: 1 / 4
Spectrin alpha-1 Antibody (PA5-114843) in IHC (P)
Immunohistochemistry analysis of Spectrin alpha-1 in mouse kidney tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-114843) at a dilution of 1:100. Secondary staining was applied with HRP conjugated anti-Rabbit.
Product Details
PA5-114843
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SPTA1(Accession P02549), corresponding to amino acid residues M2376-N2419.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total alpha 1 Spectrin.
Target Information
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia. [provided by RefSeq, Jul 2008]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-I spectrin; alpha-spectrin 1, erythroid; elliptocytosis 2; Erythroid alpha-spectrin; erythroid spectrin alpha; hemolytic anemia; mutant alpha spectrin; neuroscience mutagenesis facility, 4; spectrin alpha 1; spectrin alpha chain, erythrocyte; Spectrin alpha chain, erythrocytic 1; spectrin, alpha, erythrocytic 1 (elliptocytosis 2); spherocytosis
Gene Aliases: AF093576; AI451697; EL2; ha; HPP; HS3; ihj; nmf4; sph; SPH3; Spna-1; Spna1; SPTA; SPTA1
UniProt ID: (Human) P02549, (Mouse) P08032
Entrez Gene ID: (Human) 6708, (Rat) 289257, (Mouse) 20739
MAPK cascade
lymphocyte homeostasis
porphyrin-containing compound biosynthetic process
ER to Golgi vesicle-mediated transport
plasma membrane organization
actin filament organization
axon guidance
regulation of cell shape
hemopoiesis
positive regulation of protein binding
positive regulation of T cell proliferation
positive regulation of GTPase activity
actin filament capping
biological_process
actin cytoskeleton organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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