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Invitrogen
Spectrin beta-3 Polyclonal Antibody
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FIGURE: 1 / 3
Spectrin beta-3 Antibody (PA1-46008) in ICC/IF
Immunocytochemistry analysis of Spectrin beta-3 in Neuro 2A cells. Samples were incubated with Spectrin beta-3 polyclonal antibody (Product # PA1-46008) followed by Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).
Product Details
PA1-46008
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Residues 2150 and 2200 of Spectrin beta 3.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/tris phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-III spectrin; glutamate transporter EAAT4-associated protein 41; Spectrin Beta; spectrin beta chain, brain 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; Spinocerebellar ataxia 5 protein
Gene Aliases: GTRAP41; KIAA0302; SCA5; SCAR14; SPTBN2
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712
MAPK cascade
ER to Golgi vesicle-mediated transport
cytoskeleton organization
axon guidance
synapse assembly
vesicle-mediated transport
antigen processing and presentation of exogenous peptide antigen via MHC class II
cerebellar Purkinje cell layer morphogenesis
adult behavior
multicellular organism growth
positive regulation of GTPase activity
actin filament capping
cellular response to ethanol
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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