This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: PPPSTQAPSV NGVCTDGEPS QPLLGQQRLE HSSFPEGPGP GSGDEANGPR GERQTRTRGP APSAMPQSRS TESAH
Highest antigen sequence identity to the following orthologs: Mouse - 77%, Rat - 79%.
Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane. Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. [provided by RefSeq, Dec 2009]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Beta-III spectrin; glutamate transporter EAAT4-associated protein 41; KIAA0302; SCA5; spectrin beta chain, brain 2; Spectrin beta chain, non-erythrocytic 2; spectrin beta III sigma 2; spectrin, beta, non-erythrocytic 2; spectrin, non-erythroid beta chain 2; Spinocerebellar ataxia 5 protein; SPTBN2
Gene Aliases: GTRAP41; KIAA0302; SCA5; SCAR14; SPTBN2
UniProt ID: (Human) O15020
Entrez Gene ID: (Human) 6712