This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated. View Details
Recommended positive controls: A431, Raji, mouse BMDM, mouse spleen.
Predicted reactivity: Mouse (87%), Rat (87%), Pig (89%), Rhesus Monkey (98%), Bovine (80%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Syk is a cytoplasmic protein tyrosine kinase that translocates to the plasma membrane upon B cell antigen receptor (BCR) or the high-affinity IgE receptor (FcepsilonRI) triggering, and phosphorylates downstream adaptor proteins, thereby providing docking sites for initiation of subsequent signaling pathways, such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes. Syk binds to the receptor assemblies through interactions of its pair of SH2 domains with ITAM motives of the receptor, which have been phosphorylated by Src-family kinases. These kinases also help to activate Syk by phosphorylation of its activation loop.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DKFZp313N1010; EC 126.96.36.199; FLJ25043; FLJ37489; HGNC:11205; kinase Syk; KSYK; p72-Syk; p72Syk; SP1; Spleen tyrosine kinase; syk signaling; tyrosine-kinase syk; Tyrosine-protein kinase SYK
Gene Aliases: p72-Syk; p72syk; ptk72; SYK; Sykb
Molecular Function: kinase modulator