Positive Samples: HL-60, Mouse heart; Cellular Location: Cell membrane, Cytoplasm, cytosol
This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumor suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: p72-Syk; p72Syk; Spleen tyrosine kinase; Tyrosine-protein kinase SYK
Gene Aliases: p72-Syk; p72syk; ptk72; SYK; Sykb